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羟基化富勒烯促进去卵巢合并2型糖尿病小鼠的骨折愈合。

Hydroxylated fullerene promotes fracture healing in ovariectomized combined type 2 diabetic mice.

作者信息

Hu Yunpeng, Feng Linjie, Li Jie, Cao Fuyuan, Hou Xiaoli, Chen Wei, Zhang Yimeng, Xing Lei, Gao Jingyuan, Zhang Liu, Liu Ye, Tian Faming

机构信息

School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000, PR China.

Department of Orthopedic Surgery, The Second Hospital of Tangshan, Tangshan, Hebei, 063000, China.

出版信息

J Orthop Surg Res. 2025 Jun 19;20(1):602. doi: 10.1186/s13018-025-05997-5.

DOI:10.1186/s13018-025-05997-5
PMID:40537773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12178074/
Abstract

BACKGROUND

The aim of this investigation was to assess the interventional role of hydroxylated fullerene in this model by histological, imaging, and biomechanical means in order to inform the treatment of fracture healing in a population of menopausal women with type 2 diabetes mellitus (T2DM).

METHODS

Sixty-four female 8-week-old C57BL/6 mice were randomly divided into four groups: fracture (F), OVX + fracture (OF), T2DM + OVX + fracture (DOF), and hydroxylated fullerene-treated DOF (DOFF). A closed fracture was established in the right tibia of each mouse, which was performed 8 weeks after undergoing ovariectomy (OVX) in the OF, DOF, and DOFF groups. Hydroxylated fullerene (5 mg/kg, every two days) was administered intraperitoneally to the DOFF group starting the day after fracture. The right tibias were collected at 7 and 28 days post-fracture.

RESULTS

The systemic administration of hydroxylated fullerene significantly increased the microstructural parameters of the callus (including bone volume fraction [BV/TV] and connectivity density [Conn.D]), promoted BMP-2 expression and inhibited TNF-α expression in the callus at 7 days post-fracture, and increased the expression of type I collagen (COL1) and osteocalcin (OCN) in the callus at 28 days post-fracture.

CONCLUSION

Hydroxylated fullerene may improve fracture healing in this diabetic mouse model by reducing the inflammatory response and promoting osteogenesis. These results suggest that hydroxylated fullerene may act as a therapeutic agent for fracture healing.

摘要

背景

本研究旨在通过组织学、影像学和生物力学方法评估羟基化富勒烯在该模型中的干预作用，为绝经后2型糖尿病（T2DM）女性人群的骨折愈合治疗提供依据。

方法

将64只8周龄雌性C57BL/6小鼠随机分为四组：骨折组（F）、去卵巢+骨折组（OF）、T2DM+去卵巢+骨折组（DOF）和羟基化富勒烯治疗的DOF组（DOFF）。对每组小鼠的右胫骨造成闭合性骨折，其中OF、DOF和DOFF组在去卵巢（OVX）8周后进行骨折操作。骨折后次日开始，对DOFF组小鼠腹腔注射羟基化富勒烯（5mg/kg，每两天一次）。在骨折后7天和28天收集右胫骨。

结果

全身给予羟基化富勒烯可显著增加骨痂的微观结构参数（包括骨体积分数[BV/TV]和连接密度[Conn.D]），在骨折后7天促进骨痂中骨形态发生蛋白-2（BMP-2）表达并抑制肿瘤坏死因子-α（TNF-α）表达，在骨折后28天增加骨痂中I型胶原蛋白（COL1）和骨钙素（OCN）的表达。

结论

羟基化富勒烯可能通过减轻炎症反应和促进成骨作用来改善该糖尿病小鼠模型的骨折愈合。这些结果表明羟基化富勒烯可能作为一种骨折愈合的治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/2578806053c8/13018_2025_5997_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/065922f95e97/13018_2025_5997_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/da25377651cf/13018_2025_5997_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/e74f752c1a99/13018_2025_5997_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/92488e41f48c/13018_2025_5997_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/99b510052c85/13018_2025_5997_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/2578806053c8/13018_2025_5997_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/065922f95e97/13018_2025_5997_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/ca0a4feebbf7/13018_2025_5997_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/4c90144c3a06/13018_2025_5997_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/f0dd587c735a/13018_2025_5997_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/da25377651cf/13018_2025_5997_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/e74f752c1a99/13018_2025_5997_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/92488e41f48c/13018_2025_5997_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/99b510052c85/13018_2025_5997_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3fa/12178074/2578806053c8/13018_2025_5997_Fig9_HTML.jpg

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本文引用的文献

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Nanoscale Adv. 2025 Apr 26. doi: 10.1039/d4na01081g.
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Effects of Jintiange on the healing of osteoporotic fractures in aged rats.金天格对老年大鼠骨质疏松性骨折愈合的影响。
J Orthop Surg Res. 2024 Dec 18;19(1):828. doi: 10.1186/s13018-024-05351-1.
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lncRNA CASC11 regulates the progress of delayed fracture healing via sponging miR-150-3p.长链非编码 RNA CASC11 通过海绵吸附 miR-150-3p 调控延迟骨折愈合的进程。
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The predictive value of stress-induced hyperglycemia parameters for delayed healing after tibial fracture post-surgery.应激性高血糖参数对胫骨骨折术后延迟愈合的预测价值。
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