Liu Jie, Liu Ting-Ting, Zhang Hai-Cheng, Li Chen, Wei Wei, Chao Ai-Jun
Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, No.154 of anshan Road, Heping District, Tianjin, 300052, China.
Department of Osteo-internal Medicine, Tianjin Hospital, No.406 of Jiefang South Road, Hexi District, Tianjin, 300211, China.
J Orthop Surg Res. 2024 Dec 18;19(1):828. doi: 10.1186/s13018-024-05351-1.
To examine the effects of Jintiange on enhancing the healing of osteoporotic fractures in aged rats.
An osteoporotic fracture model of femur was established using 70 SD rats (aged > 12 months), which were randomly numbered and divided into an experimental group and a control group, each with an equal sample size (n = 35). The experimental group received Jintiange capsule ingredients via intragastric administration, while the control group received an equal volume of saline via the same method. X-ray examinations were conducted at the 4th and 12th weeks to evaluate fracture healing in the rats. After 12 weeks, micro-CT scanning was employed to assess the microstructure of the healthy femurs, and the parameters of the experimental and control groups were compared.
After 4 weeks, the mean fracture healing scores were 0.78 ± 0.43 in the experimental group and 0.56 ± 0.51 in the control group. After 12 weeks, the mean scores were 1.50 ± 0.71 in the experimental group and 0.96 ± 0.68 in the control group. The scores in the experimental group were higher than those in the control group (P < 0.05). Micro-CT examination of the femurs showed an improvement trend in bone microarchitecture in the experimental group, indicated by increased bone volume fraction (BV/TV), trabecular number (Tb. N), and trabecular thickness (Tb. Th). However, these improvements were not statistically significant. A negative correlation with statistical significance was observed between trabecular separation (Tb. Sp) and fracture healing scores.
Jintiange may promote osteoporotic fracture healing in aged rats by enhancing bone microstructure.
研究金天格对促进老年大鼠骨质疏松性骨折愈合的作用。
选用70只12月龄以上的SD大鼠建立股骨骨质疏松性骨折模型，随机编号并分为实验组和对照组，每组样本量相等（n = 35）。实验组大鼠经胃内给予金天格胶囊成分，对照组大鼠采用相同方法给予等量生理盐水。分别在第4周和第12周进行X线检查，评估大鼠骨折愈合情况。12周后，采用显微CT扫描评估健康股骨的微观结构，并比较实验组和对照组的参数。
4周后，实验组骨折愈合平均评分为0.78±0.43，对照组为0.56±0.51。12周后，实验组平均评分为1.50±0.71，对照组为0.96±0.68。实验组评分高于对照组（P < 0.05）。股骨的显微CT检查显示，实验组骨微结构有改善趋势，表现为骨体积分数（BV/TV）、骨小梁数量（Tb.N）和骨小梁厚度（Tb.Th）增加。然而，这些改善无统计学意义。观察到骨小梁间距（Tb.Sp）与骨折愈合评分之间存在具有统计学意义的负相关。
金天格可能通过增强骨微观结构促进老年大鼠骨质疏松性骨折的愈合。
