Alhaj Zachrieh, Almubaid Zaid, Kleto Gengi, Ahmad Nabeel, Rojas Vivian, Pinto-Cuberos Juan, Munoz Gonzalez Ayezel
Messrs. Alhaj and Almubaid are with the John Sealy School of Medicine at the University of Texas Medical Branch in Galveston, Texas and the Department of Internal Medicine at the University of Texas Medical Branch in Galveston, Texas.
Ms. Kleto is with the John Sealy School of Medicine at the University of Texas Medical Branch in Galveston, Texas and the Department of Dermatology at the University of Texas Medical Branch in Galveston, Texas.
J Clin Aesthet Dermatol. 2025 May 1;18(5):20-25.
Hidradenitis suppurativa (HS) is an inflammatory skin condition that presents with nodules or abscesses associated with sinus tracts. Inflammatory bowel diseases (IBD) are inflammatory gastrointestinal (GI) conditions presenting with irregular bowel movements. Although HS and IBDs may have similarities in their clinical presentation and pathophysiology, they can differ in their cutaneous manifestations. Both conditions are potentially caused by genetic changes in the human leukocyte antigen (HLA), cause skin inflammation, and are characterized by abscesses in the GI and sinus tracts.
We sought to determine the extent of coincident IBD and HS and the associated risk factors.
The Ovid Medline database was searched for all current literature on the correlations between HS and IBD. Articles were then included and removed according to specific inclusion and exclusion criteria, and a systematic review was performed on the remaining articles.
Thirteen papers that met the inclusion and the exclusion criteria were selected, and after data collection, a significant correlation was found between the development of HS and IBD. Most of the articles reviewed stated that the corresponding association was a causal link between the two diseases. Furthermore, there were various risk factors and comorbidities associated with HS and the development of IBD, including smoking, obesity, perianal disease, and genetic predispositions such as HLA-B27 mutations.
Studies show that there is a potential correlation with HS and IBDs. Additional research should to determine the genetic correlations between HS and IBDs and the underlying pathophysiological mechanism.
化脓性汗腺炎（HS）是一种炎症性皮肤病，表现为与窦道相关的结节或脓肿。炎症性肠病（IBD）是炎症性胃肠道疾病，表现为排便不规律。尽管HS和IBD在临床表现和病理生理学上可能有相似之处，但它们的皮肤表现可能不同。这两种疾病都可能由人类白细胞抗原（HLA）的基因变化引起，都会导致皮肤炎症，并且都以胃肠道和窦道中的脓肿为特征。
我们试图确定IBD与HS同时存在的程度以及相关危险因素。
在Ovid Medline数据库中搜索关于HS与IBD相关性的所有现有文献。然后根据特定的纳入和排除标准纳入和剔除文章，并对其余文章进行系统评价。
选择了13篇符合纳入和排除标准的论文，在收集数据后，发现HS与IBD的发生之间存在显著相关性。大多数综述文章指出，相应的关联是这两种疾病之间的因果联系。此外，与HS和IBD的发生相关的危险因素和合并症有多种，包括吸烟、肥胖、肛周疾病以及诸如HLA - B27突变等遗传易感性。
研究表明HS与IBD之间存在潜在相关性。应进行更多研究以确定HS与IBD之间的遗传相关性以及潜在的病理生理机制。
