Ross Yael, Ballou Stanley
Department of Rheumatology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, USA.
Rheumatol Adv Pract. 2021 Dec 27;6(2):rkab108. doi: 10.1093/rap/rkab108. eCollection 2022.
There is thought to be an association between hidradenitis suppurativa (HS) and autoimmune diseases. This retrospective longitudinal cohort study looked to identify whether certain autoimmune diseases or autoantibody specificities are more closely associated with HS than others and whether such associations are related to the severity of HS.
Patients were identified using the SlicerDicer search tool in Epic from 1 January 2010 to 15 August 2020. Search criteria included HS diagnosis by ICD-10 code (L73.2) and at least one visit to the dermatology department. Charts were reviewed to determine HS disease severity, treatment modalities, presence of autoimmune disease and autoantibody positivity.
Six hundred and twenty-seven patients were identified. Most patients were female (75.3%) and had obese BMIs (71.1%), but there were no significant demographic differences between HS patients with and without autoimmune diseases. One hundred and one (16.1%) patients in the total cohort had at least one autoimmune disease, most commonly thyroid disease, lupus, psoriasis and IBD. Two hundred and twelve patients were also tested for the presence of autoantibodies. The most common positive autoantibody, found in 54 patients (28.4%), was ANA. Fifty-four patients with more severe HS disease manifestations required biologic medications to treat their HS. Neither HS severity nor biologic treatment was associated with presence of autoimmune disease or positive autoantibodies.
In a large cohort of patients with HS followed longitudinally, autoimmune disorders (especially lupus, psoriasis and IBD) and presence of autoantibodies were more commonly observed than expected in the normal population.
化脓性汗腺炎（HS）与自身免疫性疾病之间被认为存在关联。这项回顾性纵向队列研究旨在确定某些自身免疫性疾病或自身抗体特异性是否比其他疾病与HS的关联更为密切，以及这种关联是否与HS的严重程度相关。
使用Epic中的SlicerDicer搜索工具，从2010年1月1日至2020年8月15日识别患者。搜索标准包括通过ICD - 10编码（L73.2）诊断为HS以及至少一次皮肤科就诊。查阅病历以确定HS疾病严重程度、治疗方式、自身免疫性疾病的存在情况和自身抗体阳性情况。
共识别出627例患者。大多数患者为女性（75.3%）且BMI肥胖（71.1%），但患有和未患有自身免疫性疾病的HS患者在人口统计学上无显著差异。总队列中有101例（16.1%）患者至少患有一种自身免疫性疾病，最常见的是甲状腺疾病、狼疮、银屑病和炎症性肠病（IBD）。212例患者还进行了自身抗体检测。在54例患者（28.4%）中发现的最常见阳性自身抗体是抗核抗体（ANA）。54例有更严重HS疾病表现的患者需要生物制剂来治疗他们的HS。HS严重程度和生物治疗均与自身免疫性疾病的存在或自身抗体阳性无关。
在一个纵向随访的大量HS患者队列中，自身免疫性疾病（尤其是狼疮、银屑病和IBD）和自身抗体的存在比正常人群中预期的更为常见。
