Bidgoli Fatemeh Aghighi, Talaei Sayyed Alireza, Tameh Abolfazl Azami, Salami Mahmoud
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Neurobiol Stress. 2025 Jun 1;37:100736. doi: 10.1016/j.ynstr.2025.100736. eCollection 2025 Jul.
Bidirectional communication between the gut microbiota and the nervous system founded the gut-microbiota-brain axis, substantially affects numerous vital functions of the body. Stress, as the body's natural reaction to stressful situations, in turn, affects the functioning of various organs. Through evaluating long-term potentiation (LTP) and spatial memory assessment using the Morris water maze, we aimed to examine the effect of prenatal stress on the electrophysiological and behavioral aspects of hippocampus-dependent spatial memory. The relationship of the synaptic plasticity and learning and memory with the hypothalamus-pituitary-adrenal (HPA) axis and the integrity of blood-brain and intestinal barriers were also examined. The experimental subjects were introduced to probiotic treatment to assess how the supplementation influences stress-related alterations. The prenatal stress effectively impaired both LTP occurrence and behavioral function. It also led to disruption of blood-brain and gut barriers and increased serum level of corticosterone. The probiotic supplementation positively affected the synaptic plasticity and learning and memory. It also improved the integrity of both barriers and reduced the stress hormone corticosterone. Whereas there is a reverse relationship between stress and the hippocampus-dependent spatial memory, normal stress hormone, and the integrity of intestinal and brain barriers, the probiotic supplements improve all impairments. We conclude that the HPA axis plus the blood-brain and intestinal barriers play a role in hippocampus-dependent spatial memory that are substantially affected by the beneficial gut and probiotic bacteria.
肠道微生物群与神经系统之间的双向通信建立了肠道-微生物群-脑轴，对身体的许多重要功能产生重大影响。压力作为身体对压力情况的自然反应，反过来又会影响各个器官的功能。通过使用莫里斯水迷宫评估长时程增强（LTP）和空间记忆，我们旨在研究产前压力对海马体依赖性空间记忆的电生理和行为方面的影响。还研究了突触可塑性以及学习和记忆与下丘脑-垂体-肾上腺（HPA）轴以及血脑屏障和肠道屏障完整性之间的关系。将实验对象引入益生菌治疗，以评估补充剂如何影响与压力相关的改变。产前压力有效地损害了LTP的发生和行为功能。它还导致血脑屏障和肠道屏障的破坏，并增加了血清皮质酮水平。补充益生菌对突触可塑性以及学习和记忆产生了积极影响。它还改善了两种屏障的完整性，并降低了应激激素皮质酮。虽然压力与海马体依赖性空间记忆、正常应激激素以及肠道和脑屏障的完整性之间存在反向关系，但益生菌补充剂改善了所有损伤。我们得出结论，HPA轴以及血脑屏障和肠道屏障在海马体依赖性空间记忆中发挥作用，而有益的肠道细菌和益生菌会对其产生重大影响。
