Saripalli Aishwarya, Deemer Elaine, Fox Kasey
Internal Medicine, University of California Los Angeles (UCLA) Kern Medical, Bakersfield, USA.
Geriatrics, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Cureus. 2025 Jun 18;17(6):e86327. doi: 10.7759/cureus.86327. eCollection 2025 Jun.
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon form of Hodgkin lymphoma (HL). It commonly presents as chronic, asymptomatic, slow-growing peripheral lymphadenopathy. Central nervous system involvement in NLPHL is rare. Here we report a case of a 28-year-old male patient who presented with a seven-week history of headache and neck pain. The evaluation revealed a diagnosis of subacute meningitis. He was newly diagnosed with NLPHL on lymph node biopsy. With this presentation of subacute aseptic meningitis with a negative workup for infectious, autoimmune etiology, and absence of malignant cells in the CSF, in the setting of newly diagnosed NLPHL, a diagnosis of paraneoplastic aseptic meningitis was made. The patient improved symptomatically with the treatment of his cancer.
结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）是霍奇金淋巴瘤（HL）的一种罕见形式。它通常表现为慢性、无症状、生长缓慢的外周淋巴结病。NLPHL累及中枢神经系统较为罕见。在此，我们报告一例28岁男性患者，其有7周的头痛和颈部疼痛病史。评估显示诊断为亚急性脑膜炎。经淋巴结活检，他被新诊断为NLPHL。鉴于该患者表现为亚急性无菌性脑膜炎，感染性、自身免疫性病因检查均为阴性，脑脊液中无恶性细胞，且为新诊断的NLPHL，故诊断为副肿瘤性无菌性脑膜炎。患者经癌症治疗后症状有所改善。
