Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.
Br J Haematol. 2014 Oct;167(2):238-42. doi: 10.1111/bjh.12997. Epub 2014 Jun 26.
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.
结节性淋巴细胞为主型霍奇金淋巴瘤（NLPHL）是一种罕见的淋巴瘤实体。我们进行了配对分析，以评估这种独特的霍奇金淋巴瘤亚型中几种组织病理学特征的预后影响。NLPHL 患者的淋巴结样本检测了恶性淋巴细胞为主细胞的 CD15、IgD、磷酸化 STAT6、ICOS 和 Epstein-Barr 病毒状态，以及微环境中的上皮样细胞簇和活化的 T 细胞。这些特征均与特定的临床结局无关。然而，表现为上皮样细胞簇的患者复发率较低，这一趋势虽无统计学意义，但仍值得进一步研究该标志物。
