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左氧氟沙星诱发的全身性固定性药疹。

Levofloxacin-Induced Generalized Fixed Drug Eruption.

作者信息

Martínez Jiménez Hiebda Sofía

机构信息

Internal Medicine, Centro Médico Nacional Siglo XXI, Mexico City, MEX.

出版信息

Cureus. 2025 Jun 19;17(6):e86372. doi: 10.7759/cureus.86372. eCollection 2025 Jun.

DOI:10.7759/cureus.86372
PMID:40538704
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12178587/
Abstract

Fixed drug eruption (FDE) is a type of toxicodermatitis induced by a delayed hypersensitivity reaction (type IV) characterized by the reappearance of erythematous-violaceous plaques at the same site upon reexposure to the triggering agent. We present the case of a 72-year-old female who developed a generalized FDE following the administration of levofloxacin. Diagnosis was established clinically and supported by the Naranjo algorithm. The condition improved upon drug discontinuation. This case highlights the importance of recognizing less common presentations, such as generalized FDE, and the need for continued awareness among healthcare providers, especially given the frequent use of antibiotics like levofloxacin.

摘要

固定性药疹（FDE）是一种由迟发型超敏反应（IV型）引起的中毒性皮肤病，其特征是再次接触诱发剂时，相同部位会再次出现红斑-紫斑。我们报告一例72岁女性在服用左氧氟沙星后发生全身性固定性药疹的病例。临床诊断成立，并得到了纳兰霍算法的支持。停药后病情有所改善。该病例强调了识别如全身性固定性药疹等不常见表现的重要性，以及医疗服务提供者持续保持警惕的必要性，尤其是考虑到左氧氟沙星等抗生素的频繁使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4155/12178587/3532fe14555b/cureus-0017-00000086372-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4155/12178587/b58e3aad81eb/cureus-0017-00000086372-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4155/12178587/3532fe14555b/cureus-0017-00000086372-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4155/12178587/b58e3aad81eb/cureus-0017-00000086372-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4155/12178587/3532fe14555b/cureus-0017-00000086372-i02.jpg

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本文引用的文献

1
Fixed drug eruption and generalized bullous fixed drug eruption: Insights from an analysis of the FDA Adverse Event Reporting System.
J Allergy Clin Immunol Pract. 2025 Jan;13(1):236-237.e1. doi: 10.1016/j.jaip.2024.09.024. Epub 2024 Oct 1.
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Nimesulide-Induced Fixed Drug Eruption Followed by Etoricoxib-Induced Fixed Drug Eruption: An Unusual Case Report and Review of the Literature.尼美舒利诱发的固定性药疹继以依托考昔诱发的固定性药疹：一例罕见病例报告及文献复习
J Clin Med. 2024 Mar 10;13(6):1583. doi: 10.3390/jcm13061583.
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Current Perspectives on Severe Drug Eruption.当前对严重药物疹的看法。
Clin Rev Allergy Immunol. 2021 Dec;61(3):282-298. doi: 10.1007/s12016-021-08859-0. Epub 2021 Jul 17.
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Fixed Drug Eruptions: An Update, Emphasizing the Potentially Lethal Generalized Bullous Fixed Drug Eruption.固定性药物疹：更新，强调潜在致命的全身性大疱性固定性药物疹。
Am J Clin Dermatol. 2020 Jun;21(3):393-399. doi: 10.1007/s40257-020-00505-3.
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Am J Clin Dermatol. 2000 Sep-Oct;1(5):277-85. doi: 10.2165/00128071-200001050-00003.
8
A method for estimating the probability of adverse drug reactions.一种估算药物不良反应概率的方法。
Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.