Palisaded Encapsulated (Solitary Circumscribed) Neuroma Affecting the Lip Aesthetics: Case Report and Literature Review.

Palisaded encapsulated (solitary circumscribed) neuroma (PEN) is a benign nerve sheath tumor, considered a reactive rather than a neoplastic lesion, predominantly found in the head and neck skin and oral mucosa. In the lip regions, less than 20 cases of PEN have been reported, and the differential diagnosis is a challenge. We present a 40-year-old male with a long-standing asymptomatic nodule on the lower lip, causing significant aesthetic discomfort, and a literature review of this tumor in the lips. After surgical excision, the histopathological analysis associated with immunohistochemical markers was essential for establishing the PEN diagnosis in the lower lip. Although rare, the PEN in the lip region can cause significant patient aesthetic discomfort, and histopathological analysis is crucial to distinguish this benign neural tumor from other long-standing lesions in the vermillion of the lips.