Gutierrez O, Lehy T, René E, Grès L, Bonfils S
Dig Dis Sci. 1985 Nov;30(11):1034-42. doi: 10.1007/BF01315600.
Epithelial cell proliferation in the fundic and antral mucosae was studied in 19 duodenal ulcer patients, 11 patients having undergone fundic superselective vagotomy for duodenal ulcer, and 10 controls. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautography. Except for increased fundic mucosal height, duodenal ulcer patients did not differ from controls for all parameters studied. In vagotomized patients, as compared to the other two groups, the labeling index was significantly enhanced in the innervated antral mucosa where atrophic gastritis developed, but there was no change in the labeling index and no worsening of mucosal inflammation in the denervated fundic mucosa. The only abnormality in the latter was a striking expansion, towards the surface, of the proliferative area within the fundic pit. The labeling indices and the degree of gastritis in gastric mucosae are significantly correlated in control and duodenal ulcer patients. After superselective vagotomy, this correlation still existed in antral mucosa (r = 0.88, P less than 0.001) but not in fundic mucosa. If findings in antral mucosa, after superselective vagotomy, seemed related to gastritis lesions, those in fundic mucosa were not and may indicate an alteration due to the vagotomy per se.
对19例十二指肠溃疡患者、11例因十二指肠溃疡接受胃底超选择性迷走神经切断术的患者以及10例对照者的胃底和胃窦黏膜上皮细胞增殖情况进行了研究。这是通过在黏膜活检中体外掺入氚标记胸腺嘧啶核苷并进行放射自显影来实现的。除胃底黏膜高度增加外，十二指肠溃疡患者在所有研究参数方面与对照者并无差异。与其他两组相比，迷走神经切断术患者中，发生萎缩性胃炎的受神经支配的胃窦黏膜标记指数显著升高，但去神经支配的胃底黏膜标记指数无变化，黏膜炎症也未加重。后者唯一的异常是胃小凹内增殖区向表面显著扩展。在对照者和十二指肠溃疡患者中，胃黏膜的标记指数与胃炎程度显著相关。超选择性迷走神经切断术后，这种相关性在胃窦黏膜中仍然存在（r = 0.88，P < 0.001），但在胃底黏膜中不存在。超选择性迷走神经切断术后，胃窦黏膜的表现似乎与胃炎病变有关，而胃底黏膜的表现并非如此，可能表明是迷走神经切断术本身导致的改变。
