羰基衍生物向1-氟-2-卤代乙基骨架的偕二氟氟化反应。
Geminal homologative fluorination of carbonyl derivatives to 1-fluoro-2-haloethyl skeletons.
作者信息
Miele Margherita, Castiglione Davide, Prado-Roller Alexander, Castoldi Laura, Pace Vittorio
机构信息
Department of Chemistry, University of Turin, Via Giuria 7, 10125 Turin, Italy.
Institute of Inorganic Chemistry, University of Vienna, Waehringerstrasse 42, 1090, Vienna, Austria.
出版信息
Chem Commun (Camb). 2025 Jun 20. doi: 10.1039/d5cc01542a.
Abstract
Carbonyl groups undergo the sequential installation of two nucleophilic elements, halomethyl and fluoride moieties. This formal -difunctionalization enables the preparation-under full chemocontrol - of vic-fluorohaloethanes by simply defining the C1 nucleophile, thus enabling access to all combinations of the four halogens.
摘要
羰基会依次引入两个亲核基团，即卤甲基和氟基团。这种形式上的双官能化反应能够在完全化学控制的条件下，通过简单地确定C1亲核试剂来制备邻位氟卤乙烷，从而能够得到四种卤素的所有组合。
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