Kanayama Seisaku, Watanabe Kentaro, Tanaka Minoru, Takita Junko, Todo Tomoki
Division of Innovative Cancer Therapy and Department of Surgical Neuro-Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Cancer Sci. 2025 Sep;116(9):2607-2612. doi: 10.1111/cas.70126. Epub 2025 Jun 20.
Genetic and cell biological analyses of this rare glioblastoma (GBM) case with rapidly progressive pleural metastasis revealed essential roles of epithelial-mesenchymal transition (EMT) and glioma stem-like cells (GSCs) in extraneural metastasis. Contrary to the common prediction, the metastatic lesion shared 73% of mutations and two fusion genes with the primary but not the recurrent tumor, indicating that extraneural metastasis occurs early in GBM progression. Functional assays using primary tumor-derived GSCs confirmed EMT-enhanced migratory behaviors. EMT and genetically driven early tumor seedings are crucial for extraneural GBM metastasis, emphasizing the need for further investigation into EMT pathways and GSC biology.
对这例伴有快速进展性胸膜转移的罕见胶质母细胞瘤（GBM）病例进行的遗传学和细胞生物学分析揭示了上皮-间质转化（EMT）和胶质瘤干细胞（GSCs）在神经外转移中的重要作用。与常见预测相反，转移病灶与原发肿瘤而非复发肿瘤共享73%的突变和两个融合基因，这表明神经外转移发生在GBM进展的早期。使用原发肿瘤来源的GSCs进行的功能分析证实了EMT增强的迁移行为。EMT和基因驱动的早期肿瘤播散对于神经外GBM转移至关重要，强调了进一步研究EMT途径和GSC生物学的必要性。
