Division of Stereotactic Neurosurgery, Department of General Neurosurgery, University Medical Center Freiburg, Freiburg, Germany.
Cancer Lett. 2012 Dec 1;325(1):42-53. doi: 10.1016/j.canlet.2012.05.024. Epub 2012 May 28.
Here we show that activation of the canonical WNT/β-catenin pathway increases the expression of stem cell genes and promotes the migratory and invasive capacity of glioblastoma. Modulation of WNT signaling alters the expression of epithelial-to-mesenchymal transition activators, suggesting a role of this process in the regulation of glioma motility. Using immunohistochemistry in patient-derived glioblastoma samples we showed higher numbers of cells with intranuclear signal for β-catenin in the infiltrating edge of tumor compared to central tumor parenchyma. These findings suggest that canonical WNT/β-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target.
在这里，我们表明经典 WNT/β-连环蛋白途径的激活会增加干细胞基因的表达，并促进神经胶质瘤的迁移和侵袭能力。WNT 信号的调节会改变上皮-间充质转化激活剂的表达，这表明该过程在调节神经胶质瘤的运动中起作用。通过对患者来源的神经胶质瘤样本进行免疫组织化学分析，我们发现与肿瘤中心实质相比，肿瘤浸润边缘的细胞中β-连环蛋白的核内信号数量更高。这些发现表明经典 WNT/β-连环蛋白途径是 GBM 侵袭的关键调节剂，可能代表一个潜在的治疗靶点。
