Tai Yunhao, Cheng Qilong, Liu Yuteng, Lu Xingqi, Xu Ting, Li Xiaojian, Liu Ping, Luo Tingting, Liu Guangli, Gan Yijing, Yang Runhuai
School of Biomedical Engineering, 3D-Printing and Tissue Engineering Center, Anhui Medical University, Hefei 230032, China.
Key Laboratory of Process Optimization and Intelligent Decision-making, School of Management, Hefei University of Technology, Hefei 230009, China.
ACS Sens. 2025 Jul 25;10(7):4996-5007. doi: 10.1021/acssensors.5c00883. Epub 2025 Jun 20.
Intelligent intraocular pressure (IOP) sensors capable of continuous monitoring play a crucial role in the treatment of glaucoma. However, early diagnosis and treatment continue to face significant challenges due to the unique physiological environment of the eye. The primary scientific challenge lies in developing a method for continuous, high-sensitivity IOP monitoring that does not damage corneal tissue. To address this issue, a novel smart contact lens was developed, integrating hydrogel-based micronano architectures with diffraction-grating-embedded films. This device leverages 3D printing technology to achieve conformal adhesion to the ocular surface, enabling real-time IOP monitoring through optical-to-digital signal transduction. Additionally, ex vivo porcine eyeballs were used for in vitro testing and evaluation to quantitatively demonstrate the performance of the smart sensor. The results indicate that the smart contact lens developed in this study exhibits excellent biocompatibility and a high sensitivity of 2.5% mmHg within the range of 0-50 mmHg, enabling precise IOP monitoring. These lenses hold significant potential for clinical IOP monitoring and demonstrate substantial promise for the next generation of ocular disease prevention.
能够进行连续监测的智能眼压（IOP）传感器在青光眼治疗中起着至关重要的作用。然而，由于眼睛独特的生理环境，早期诊断和治疗仍然面临重大挑战。主要的科学挑战在于开发一种能够连续、高灵敏度地监测眼压且不损伤角膜组织的方法。为了解决这个问题，研发了一种新型智能隐形眼镜，它将基于水凝胶的微米纳米结构与嵌入衍射光栅的薄膜相结合。该设备利用3D打印技术实现与眼表的贴合，通过光信号到数字信号的转换实现眼压的实时监测。此外，使用离体猪眼球进行体外测试和评估，以定量展示智能传感器的性能。结果表明，本研究开发的智能隐形眼镜具有优异的生物相容性，在0至50 mmHg范围内灵敏度高达2.5%/mmHg，能够实现精确的眼压监测。这些隐形眼镜在临床眼压监测方面具有巨大潜力，为下一代眼部疾病预防展现出可观的前景。
