1-α-羟维生素D3治疗的甲状旁腺功能减退患儿中糖皮质激素诱发的低钙血症

Hypocalcaemia induced by glucocorticoids in a child with hypoparathyroidism treated with 1-alpha-hydroxyvitamin D3.

作者信息

Vardi P, Benderly A, Etzioni A, Levy J, Hochberg Z

出版信息

Eur J Pediatr. 1985 Sep;144(3):280-2. doi: 10.1007/BF00451962.

DOI:10.1007/BF00451962

Abstract

Glucocorticoids tend to lower the intestinal absorption of calcium, leading to a negative calcium balance. A 7-year-old girl with hypoparathyroidism was maintained as normocalcaemic on 1-alpha-hydroxyvitamin D3 (1 alpha D3) and calcium gluconate lactate. During an episode of aplastic anaemia she was treated with prednisolone, with a subsequent dramatic fall of serum calcium despite 1 alpha D3 treatment and serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in the high-normal range. Glucocorticoids seem to have interfered directly with cellular events responsible for intestinal absorption of calcium.

摘要

糖皮质激素往往会降低肠道对钙的吸收，导致钙平衡呈负性。一名患有甲状旁腺功能减退症的7岁女孩通过服用1α-羟维生素D3（1αD3）和葡萄糖酸钙乳酸盐维持血钙正常。在再生障碍性贫血发作期间，她接受了泼尼松龙治疗，尽管进行了1αD3治疗且血清1,25-二羟维生素D3（1,25(OH)2D3）处于高正常范围，但血清钙随后仍急剧下降。糖皮质激素似乎直接干扰了负责肠道钙吸收的细胞活动。