Jorgensen H, Vogt J H
Acta Med Scand. 1977 Jan;201(1-2):3-7. doi: 10.1111/j.0954-6820.1977.tb15646.x.
In two patients (father and daughter) with idiopathic hypoparathyroidism, one of whom was resistant to the action of vitamin D2 and AT-10, 1alpha-hydroxycholecalciferol (1alpha-(OH)D3) in doses of 2-5 mug/day restored the serum calcium concentration to the normal range. The calcemic effect of 1alpha (OH)D3 was in both patients due to an increased intestinal calcium absorption and increased calcium mobilization from bone. In one of the patients 1alpha-(OH)D3 also increased the renal tubular calcium reabsorption; in the other it did not have this effect, resulting in hypercalciuria as serum calcium rose. The lack of effect on tubular calcium reabsorption probably accounts for the relative resistance to the action of 1alpha-(OH)C3 in this patient compared with other.
在两名患有特发性甲状旁腺功能减退症的患者（父女）中，其中一人对维生素D2和AT - 10的作用有抵抗，每日剂量为2 - 5微克的1α - 羟胆钙化醇（1α-(OH)D3）将血清钙浓度恢复到正常范围。在这两名患者中，1α(OH)D3的血钙升高作用是由于肠道钙吸收增加以及骨钙动员增加。在其中一名患者中，1α-(OH)D3还增加了肾小管对钙的重吸收；在另一名患者中则没有这种作用，导致随着血清钙升高出现高钙尿症。对肾小管钙重吸收缺乏作用可能解释了该患者与其他患者相比对1α-(OH)C3作用的相对抵抗性。
