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用于将肌酸激酶水平升高作为新冠病毒病初始表现进行建模的正弦指数分布。

Sinusoidal exponential distribution for modeling elevated creatinine kinase level as the initial presentation of Covid-19.

作者信息

Kilany N M, Alharpy A M

机构信息

Mathematics and Computer Science Department, Faculty of Science, Menoufia University, Shebin EL-Kom, Egypt.

Mathematics Department, Faculty of Science, Taibah University, Al-Madinah Al-Munawara, Medina, Saudi Arabia.

出版信息

Sci Rep. 2025 Jun 20;15(1):20233. doi: 10.1038/s41598-025-98836-w.

Abstract

This paper is devoted to deriving a new lifetime distribution based on a sine function to model different initial symptoms of Covid-19 patients that initially present as muscle weakness with increased Creatinine Kinase (CK), without fever or respiratory symptoms. The new distribution is called Sinusoidal Exponential Distribution. Among its interesting properties, it has the feature of possessing a periodic hazard rate function. Some of its mathematical properties are studied, including moments, moment generating function, hazard rate function, mean residual life function, reversed failure rate and Lorenz and Bonferroni Curves. The estimation of its parameter is investigated using the maximum likelihood estimation. A simulation study is carried out to assess the performance of the obtained estimators for small and large samples. Areal-life data set is considered to illustrate the usefulness and the flexibility of the proposed distribution.

摘要

本文致力于推导一种基于正弦函数的新寿命分布,以对新冠患者不同的初始症状进行建模,这些患者最初表现为肌肉无力且肌酸激酶(CK)升高,无发热或呼吸道症状。这种新分布称为正弦指数分布。在其有趣的性质中,它具有周期性危险率函数的特征。研究了它的一些数学性质,包括矩、矩生成函数、危险率函数、平均剩余寿命函数、反向失效率以及洛伦兹曲线和邦费罗尼曲线。使用最大似然估计法研究了其参数估计。进行了一项模拟研究,以评估所获得的估计量在小样本和大样本情况下的性能。考虑了一个实际生活数据集来说明所提出分布的有用性和灵活性。

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