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在单一三级转诊中心进行清洁间歇性导尿的逼尿肌活动低下和无收缩膀胱患者:现实生活中发生了什么?

Detrusor Underactivity and Acontractile Bladder Patients Performing Clean Intermittent Catheterization in a Single Tertiary Referral Center: What is Happening in Real Life?

作者信息

Dewulf Karel, Meurice Alicia, Duvillier Thibault, Van Isveldt Fons, Everaerts Wouter, Albersen Maarten, Van der Aa Frank, De Ridder Dirk

机构信息

Department of Urology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Department of Urology, AZ Delta, Deltalaan 1, 8800, Roeselare, Belgium.

出版信息

Int Urogynecol J. 2025 Jun 21. doi: 10.1007/s00192-025-06181-3.

Abstract

OBJECTIVES

Bladder emptying disorders, caused by detrusor underactivity (DU) and acontractile detrusor (ACD) are frequent conditions, where the focus of treatment is often targeted on minimizing secondary complications by bladder catheterization. If feasible, the preferred method is clean intermittent catheterization (CIC). In this study, we investigate underlying diseases, clinical and urodynamic parameters of a real-life cohort of DU and ACD patients requiring CIC.

METHODS

We performed a retrospective chart review of 133 patients performing CIC due to DU or ACD from 2015 to 2020. Demographic, clinical and urodynamic data were extracted for further analyses.

RESULTS

Of 133 patients included, 74% had ACD. Neurogenic diseases were present in 47% of patients, followed by pelvic surgery (23%) and pharmacotherapy (14%). Persistent need for bladder drainage on the long term was observed in 75% of patients. Of patients who discontinued CIC, 44% had a successful treatment. Sacral neuromodulation was the most frequent successful treatment in 56% of patients. Urine tract infections (UTIs) were present in one third of patients.

CONCLUSIONS

In this patient cohort needing CIC, ACD was more frequent than DU. Most patients who need CIC for DU or ACD require bladder drainage on the long term. Underlying neurogenic diseases are the most frequent.

摘要

目的

由逼尿肌活动低下(DU)和逼尿肌无收缩(ACD)引起的膀胱排空障碍是常见病症,治疗重点通常是通过膀胱插管将继发性并发症降至最低。若可行,首选方法是清洁间歇性导尿(CIC)。在本研究中,我们调查了需要CIC的DU和ACD患者真实队列的潜在疾病、临床和尿动力学参数。

方法

我们对2015年至2020年因DU或ACD进行CIC的133例患者进行了回顾性病历审查。提取人口统计学、临床和尿动力学数据以进行进一步分析。

结果

在纳入的133例患者中,74%患有ACD。47%的患者存在神经源性疾病,其次是盆腔手术(23%)和药物治疗(14%)。75%的患者长期需要膀胱引流。在停止CIC的患者中,44%治疗成功。骶神经调节是最常见的成功治疗方法,占患者的56%。三分之一的患者存在尿路感染(UTI)。

结论

在这个需要CIC的患者队列中,ACD比DU更常见。大多数因DU或ACD需要CIC的患者长期需要膀胱引流。最常见的潜在疾病是神经源性疾病。

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