经颅磁声刺激对MPTP诱导的帕金森病小鼠模型行为及振荡活动皮质纹状体传递的调节作用
Modulatory effects of transcranial magneto-acoustic stimulation on behavior and corticostriatal transmission of oscillatory activity in a mouse model of Parkinson's disease induced by MPTP.
作者信息
Xu Yihao, Zhang Shuai, Mi Jinrui, Lu Xiaochao, Wang Qingzhao, Fan Ruiyang, Lv Jiangwei, Xing Lipeng, Zhang Haochen, Xu Guizhi
机构信息
School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China.
School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China.
出版信息
Exp Neurol. 2025 Oct;392:115352. doi: 10.1016/j.expneurol.2025.115352. Epub 2025 Jun 19.
BACKGROUND
Transcranial magneto-acoustic stimulation (TMAS) is a novel noninvasive neuromodulation technology that combines ultrasound within a static magnetic field to achieve high spatial resolution and deep brain penetration. However, the effects of TMAS on neural oscillations related to motor deficits in Parkinson's disease (PD) remain poorly understood.
OBJECTIVE
The objective of this study was to investigate whether TMAS could enhance the propagation and interaction of oscillatory dynamics within the corticostriatal circuit.
METHODS
We performed a comprehensive neurological assessment using behavioral tests, in vivo electrophysiological recordings, and immunohistochemistry in male C57BL/6 J mice treated with MPTP, followed by noninvasive brain stimulation.
RESULTS
Our results demonstrate that TMAS: 1) improves locomotor performance and learning abilities in PD mice; 2) reduces phase-amplitude coupling between beta and gamma frequency bands of local field potentials, while enhancing inter-brain interactions and information transmission; 3) modulates neural activity and depresses c-Fos overexpression on the dorsal striatum of PD mice; 4) provides neuroprotection by modulating neuroinflammation and mitigating MPTP-induced neurotoxicity within neural circuits.
CONCLUSION
These findings highlight the role of TMAS in strengthening the functional organization of the corticostriatal circuit, suggesting its potential as a novel treatment for neuropsychiatric disorders characterized by activity disruptions.
背景
经颅磁声刺激（TMAS）是一种新型的非侵入性神经调节技术，它将超声波与静磁场相结合，以实现高空间分辨率和深部脑穿透。然而，TMAS对帕金森病（PD）运动功能障碍相关神经振荡的影响仍知之甚少。
目的
本研究的目的是探讨TMAS是否能增强皮质纹状体回路内振荡动力学的传播和相互作用。
方法
我们对用MPTP处理的雄性C57BL/6 J小鼠进行了全面的神经学评估，包括行为测试、体内电生理记录和免疫组织化学，随后进行非侵入性脑刺激。
结果
我们的结果表明，TMAS：1）改善PD小鼠的运动性能和学习能力；2）减少局部场电位的β和γ频段之间的相位-振幅耦合，同时增强脑间相互作用和信息传递；3）调节神经活动并抑制PD小鼠背侧纹状体上的c-Fos过表达；4）通过调节神经炎症和减轻神经回路内MPTP诱导的神经毒性来提供神经保护。
结论
这些发现突出了TMAS在加强皮质纹状体回路功能组织方面的作用，表明其作为一种针对以活动紊乱为特征的神经精神疾病的新型治疗方法的潜力。
Zotero 插件