Zondervan H A, Voorhorst F J, Robertson E A, Kurver P H, Massen C
Eur J Obstet Gynecol Reprod Biol. 1985 Sep;20(3):145-51. doi: 10.1016/0028-2243(85)90013-9.
Many authors have correlated changes in maternal hemodynamics during pregnancy with fetal growth. Sufficient plasma volume expansion in pregnancy seems mandatory for an optimal reproductive result. A correlation between rheological characteristics (low-shear whole blood viscosity and yield shear stress) and birthweight centiles was found in 26 third-trimester pregnancies. The level of statistical significance (P less than 0.05) was reached in nulliparous pregnancies but not in parous pregnancies. Measurements of whole blood viscosity at low shear rate and yield shear stress seem to provide information on the efficacy of placental perfusion. There have been reports in the literature to support the assumption of the prevalence of low-shear circumstances in the intervillous space. The hypothesis is put forward that, during pregnancy, the changes in maternal hemodynamics influence fetal growth by their impact on the flow through the placenta.
许多作者已将孕期母体血液动力学变化与胎儿生长联系起来。孕期充足的血浆量扩充似乎是实现最佳生殖结果所必需的。在26例孕晚期妊娠中发现流变学特征（低切变率全血粘度和屈服切应力）与出生体重百分位数之间存在相关性。在初产妇妊娠中达到了统计学显著性水平（P小于0.05），但经产妇妊娠未达到。低切变率下全血粘度和屈服切应力的测量似乎能提供胎盘灌注效果的信息。文献中有报道支持绒毛间隙中低切变情况普遍存在的假设。有人提出这样的假说，即在孕期，母体血液动力学变化通过对胎盘血流的影响来影响胎儿生长。
