Basit Abdul, Hussain Mubbashir, Qasim Muhammad, Khan Taj Ali, Naveed Hassan, Reh-Man Abdul, Shah Mian Mufarih, Fatima Madiha, Alzahrani Khalid J, Alsharif Khalaf F
1Department of Microbiology, Kohat University of Science and Technology (KUST), Kohat, Pakistan.
2Institute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar, Pakistan.
Pol J Microbiol. 2025 Jun 18;74(2):262-274. doi: 10.33073/pjm-2025-021. eCollection 2025 Jun 1.
is a significant pathogen in postpartum women and neonates. This study aimed to determine its prevalence, antibiotic susceptibility, clinical features, and associated risk factors in tertiary care hospitals in Khyber Pakhtunkhwa, Pakistan. A total of 384 clinical samples were collected from postpartum women (n = 192) and neonates (n = 192) in maternity wards. isolates were identified using standard microbiological methods, and antibiotic susceptibility was assessed via the Kirby-Bauer disk diffusion assay. The typing was performed through PCR and sequencing. Clinical features and risk factors were analyzed statistically. The overall prevalence of was 14.3% (55/384), with 16.7% in postpartum women and 11.9% in neonates. Isolates exhibited high sensitivity to β-lactams (penicillin ≥ 95%, ampicillin ≥ 91%) but moderate resistance to cephalosporins (cefepime ~12%) and macrolides (erythromycin 23.5-29.0%). Fluoroquinolones and tetracyclines showed the highest resistance rates (ciprofloxacin 38.7-43.5%, tetracycline 32.1-37.5%). Molecular typing revealed diverse types, with 44, 77, and 12 being predominant. Fever and sepsis were common, with postpartum women experiencing more wound infections (33.3%) and neonates exhibiting respiratory distress (55.6%). Significant risk factors included prolonged labor (> 18 hours, = 0.030) and premature rupture of membranes ( = 0.039) in mothers, preterm birth ( = 0.013), and neonatal resuscitation ( = 0.028) in neonates. The study highlights a substantial burden of infections and increasing antibiotic resistance. Enhanced surveillance, antibiotic stewardship, and targeted infection control strategies are crucial to mitigating morbidity and mortality in these high-risk groups.
是产后妇女和新生儿中的一种重要病原体。本研究旨在确定其在巴基斯坦开伯尔-普赫图赫瓦省三级医院中的流行情况、抗生素敏感性、临床特征及相关危险因素。共从产科病房的产后妇女（n = 192）和新生儿（n = 192）中收集了384份临床样本。使用标准微生物学方法鉴定分离株，并通过 Kirby-Bauer 纸片扩散法评估抗生素敏感性。通过PCR和测序进行分型。对临床特征和危险因素进行统计学分析。总体流行率为14.3%（55/384），产后妇女中为16.7%，新生儿中为11.9%。分离株对β-内酰胺类药物（青霉素≥95%，氨苄西林≥91%）表现出高敏感性，但对头孢菌素（头孢吡肟~12%）和大环内酯类药物（红霉素23.5 - 29.0%）有中度耐药性。氟喹诺酮类和四环素类药物显示出最高耐药率（环丙沙星38.7 - 43.5%，四环素32.1 - 37.5%）。分子分型显示出多种类型，其中44型、77型和12型为主。发热和败血症很常见，产后妇女伤口感染较多（33.3%），新生儿出现呼吸窘迫（55.6%）。母亲的显著危险因素包括产程延长（> 18小时，P = 0.030）和胎膜早破（P = 0.039），新生儿的危险因素包括早产（P = 0.013）和新生儿复苏（P = 0.028）。该研究突出了感染负担沉重及抗生素耐药性增加的问题。加强监测、抗生素管理和针对性的感染控制策略对于降低这些高危人群的发病率和死亡率至关重要。
