Liu Lulu, Li Ruoyao, Xie Lijuan, Zhang Xinxin, Gong Deyan, Zha Zhengbao, Xu Cheng-Yan, Miao Zhaohua
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China.
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China.
J Colloid Interface Sci. 2025 Dec;699(Pt 2):138222. doi: 10.1016/j.jcis.2025.138222. Epub 2025 Jun 17.
Inflammatory bowel disease (IBD), a chronic inflammatory gastrointestinal disease, is closely related to diverse inflammatory factors like reactive oxygen and nitrogen species (RONS) and cell-free DNA (cfDNA). Herein, tannic acid (TA) modified hafnium hydride nanosheets (HfH@TA NSs) with a thickness of 1-4 nm, prepared by liquid-phase exfoliation, were explored as a high-performance anti-inflammatory agent for IBD treatment. By virtue of the high specific surface area of two-dimensional structure, HfH@TA NSs can effectively not only scavenge RONS, but also eliminate cfDNA, thus inhibiting the pro-inflammatory responses. In a dextran sodium sulfate (DSS)-induced IBD mouse model, HfH@TA NSs by oral administration rapidly alleviated various IBD symptoms, including disease activity index (DAI), colon length, and the level of pro-inflammatory cytokines in 5 days, superior to the clinical drug 5-aminosalicylic acid (5-ASA). This work introduces ultrathin hafnium hydride nanosheets with RONS and cfDNA-dual scavenging capabilities as efficient two-dimensional anti-inflammatory agents for IBD treatment.
炎症性肠病（IBD）是一种慢性炎症性胃肠道疾病，与多种炎症因子密切相关，如活性氧和氮物种（RONS）以及游离DNA（cfDNA）。在此，通过液相剥离法制备的厚度为1 - 4纳米的单宁酸（TA）修饰氢化铪纳米片（HfH@TA NSs）被探索作为治疗IBD的高性能抗炎剂。凭借二维结构的高比表面积，HfH@TA NSs不仅能有效清除RONS，还能消除cfDNA，从而抑制促炎反应。在葡聚糖硫酸钠（DSS）诱导的IBD小鼠模型中，口服HfH@TA NSs在5天内迅速缓解了各种IBD症状，包括疾病活动指数（DAI）、结肠长度以及促炎细胞因子水平，优于临床药物5 - 氨基水杨酸（5 - ASA）。这项工作引入了具有RONS和cfDNA双重清除能力的超薄氢化铪纳米片作为治疗IBD的高效二维抗炎剂。
