• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

聚多巴胺修饰的氧化铈纳米棒通过清除 ROS 和调节巨噬细胞 M2 极化缓解结肠炎炎症。

Polydopamine Modified Ceria Nanorods Alleviate Inflammation in Colitis by Scavenging ROS and Regulating Macrophage M2 Polarization.

机构信息

Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.

出版信息

Int J Nanomedicine. 2023 Aug 14;18:4601-4616. doi: 10.2147/IJN.S416049. eCollection 2023.

DOI:10.2147/IJN.S416049
PMID:37600119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10437713/
Abstract

BACKGROUND

Inflammatory bowel disease (IBD) is closely related to higher intracellular oxidative stress. Therefore, developing a novel method to scavenge the harmful reactive oxygen species (ROS) and alleviate colon inflammation to treat IBD is a promising strategy.

METHODS

CeO@PDA-PEG (CeO@PP) were synthesized by modifying ceria (CeO) nanorods with polydopamine (PDA) and polyethylene glycol (PEG). The ROS scavenging ability of CeO@PP was detected by using flow cytometry and confocal laser scanning microscope (CLSM). The anti-inflammatory ability of CeO@PP was determined in vitro by treating lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The biocompatibility of CeO@PP was evaluated in vivo and in vitro. Moreover, the therapeutic effects of CeO@PP in vivo were estimated in a dextran sulfate sodium salt (DSS)-induced colitis mouse model.

RESULTS

Physicochemical property results demonstrated that PDA and PEG modification endowed CeO nanorods with excellent dispersibility and colloidal stability. CeO@PP maintained superior enzyme-like activity, including superoxide dismutase (SOD) and catalase (CAT), indicating antioxidant ability. Moreover, in vitro results showed that CeO@PP with PDA promotes LPS-induced RAW 264.7 macrophages into M2-type polarization. In addition, in vitro and in vivo results showed that CeO@PP have great biocompatibility and biosafety. Animal experiments have shown that CeO@PP have excellent anti-inflammatory effects against DSS-induced colitis and effectively alleviated intestinal mucosal injury.

CONCLUSION

The nanoplatform CeO@PP possessed excellent antioxidant and anti-inflammatory properties for scavenging ROS and modulating macrophage polarization, which is beneficial for efficient colitis therapy.

摘要

背景

炎症性肠病（IBD）与细胞内氧化应激密切相关。因此，开发一种新的方法来清除有害的活性氧（ROS）并减轻结肠炎症以治疗 IBD 是一种很有前途的策略。

方法

通过用聚多巴胺（PDA）和聚乙二醇（PEG）修饰氧化铈（CeO）纳米棒，合成了 CeO@PDA-PEG（CeO@PP）。通过流式细胞术和共聚焦激光扫描显微镜（CLSM）检测 CeO@PP 的 ROS 清除能力。通过用脂多糖（LPS）刺激 RAW 264.7 巨噬细胞来测定 CeO@PP 的抗炎能力。通过体内和体外实验评估 CeO@PP 的生物相容性。此外，还在葡聚糖硫酸钠盐（DSS）诱导的结肠炎小鼠模型中评估了 CeO@PP 的体内治疗效果。

结果

物理化学性质结果表明，PDA 和 PEG 修饰使 CeO 纳米棒具有优异的分散性和胶体稳定性。CeO@PP 保持了卓越的酶样活性，包括超氧化物歧化酶（SOD）和过氧化氢酶（CAT），表明其具有抗氧化能力。此外，体外结果表明，具有 PDA 的 CeO@PP 可促进 LPS 诱导的 RAW 264.7 巨噬细胞向 M2 型极化。此外，体外和体内结果表明，CeO@PP 具有良好的生物相容性和生物安全性。动物实验表明，CeO@PP 对 DSS 诱导的结肠炎具有出色的抗炎作用，并有效缓解了肠道黏膜损伤。

结论

纳米平台 CeO@PP 具有出色的抗氧化和抗炎特性，可清除 ROS 并调节巨噬细胞极化，有利于高效的结肠炎治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/f7ca844f2aab/IJN-18-4601-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/67c15bc62ba0/IJN-18-4601-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/8b3c532f530f/IJN-18-4601-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/c36249d9539d/IJN-18-4601-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/a2189eb42544/IJN-18-4601-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/73a0dbda64af/IJN-18-4601-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/f7ca844f2aab/IJN-18-4601-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/67c15bc62ba0/IJN-18-4601-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/8b3c532f530f/IJN-18-4601-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/c36249d9539d/IJN-18-4601-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/a2189eb42544/IJN-18-4601-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/73a0dbda64af/IJN-18-4601-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ad/10437713/f7ca844f2aab/IJN-18-4601-g0006.jpg

相似文献

1
Polydopamine Modified Ceria Nanorods Alleviate Inflammation in Colitis by Scavenging ROS and Regulating Macrophage M2 Polarization.聚多巴胺修饰的氧化铈纳米棒通过清除 ROS 和调节巨噬细胞 M2 极化缓解结肠炎炎症。
Int J Nanomedicine. 2023 Aug 14;18:4601-4616. doi: 10.2147/IJN.S416049. eCollection 2023.
2
Sophora Flos extract ameliorates inflammatory bowel disease via inhibiting the PI3K/AKT/mTOR signaling pathway activation and modulating M1/M2 polarization in macrophages.槐花提取物通过抑制PI3K/AKT/mTOR信号通路激活和调节巨噬细胞M1/M2极化来改善炎症性肠病。
Phytomedicine. 2025 Jul 23;146:157095. doi: 10.1016/j.phymed.2025.157095.
3
Multifunctional Hydrogel with Synergistic Reactive Oxygen Species Scavenging and Macrophage Polarization-Induced Osteo-immunomodulation for Enhanced Bone Regeneration.具有协同活性氧清除和巨噬细胞极化诱导骨免疫调节功能的多功能水凝胶促进骨再生
ACS Appl Mater Interfaces. 2025 Jul 9;17(27):38985-39001. doi: 10.1021/acsami.5c08737. Epub 2025 Jun 24.
4
Ultra-small Prussian blue nanodots scavenge reactive oxidative species and balance M1/M2 macrophages to mitigate colitis inflammation.超小普鲁士蓝纳米点清除活性氧化物质并平衡M1/M2巨噬细胞以减轻结肠炎炎症。
Nanoscale. 2025 Jun 26;17(25):15402-15412. doi: 10.1039/d5nr00667h.
5
DS-Modified Paeoniflorin pH-Responsive Lipid-Polymer Hybrid Nanoparticles for Targeted Macrophage Polarization in a Rat Model of Rheumatoid Arthritis.用于类风湿性关节炎大鼠模型中靶向巨噬细胞极化的DS修饰芍药苷pH响应性脂质-聚合物杂化纳米颗粒
Int J Nanomedicine. 2025 Jul 12;20:8967-8992. doi: 10.2147/IJN.S516434. eCollection 2025.
6
Akkermansia muciniphila relieves inflammatory response in DSS-induced ulcerative colitis in mice through regulating macrophage polarization via SCFAs-SLC52A2/FFAR2 pathway.嗜黏蛋白阿克曼氏菌通过短链脂肪酸-SLC52A2/游离脂肪酸受体2途径调节巨噬细胞极化，从而减轻右旋糖酐硫酸钠诱导的小鼠溃疡性结肠炎中的炎症反应。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 22. doi: 10.1007/s00210-025-03787-8.
7
[Ecliptasaponin A ameliorates DSS-induced colitis in mice by suppressing M1 macrophage polarization inhibiting the JAK2/STAT3 pathway].[墨旱莲皂苷A通过抑制M1巨噬细胞极化和JAK2/STAT3信号通路改善DSS诱导的小鼠结肠炎]
Nan Fang Yi Ke Da Xue Xue Bao. 2025 Jun 20;45(6):1297-1306. doi: 10.12122/j.issn.1673-4254.2025.06.19.
8
PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging.聚乙二醇包覆的二氧化铈-氧化锆纳米颗粒通过激活自噬通量和清除活性氧来预防体重增加和肥胖相关器官损伤。
Int J Nanomedicine. 2025 Jun 26;20:8305-8326. doi: 10.2147/IJN.S510541. eCollection 2025.
9
Lovastatin alleviates DSS-induced colitis by modulating macrophage polarization via the PPARγ-NF-κB pathway.洛伐他汀通过PPARγ-NF-κB途径调节巨噬细胞极化来减轻右旋糖酐硫酸钠诱导的结肠炎。
Int Immunopharmacol. 2025 Aug 28;161:115068. doi: 10.1016/j.intimp.2025.115068. Epub 2025 Jun 11.
10
ROS/pH Dual-Responsive Hydrogel Dressings Loaded with Amphiphilic Structured Nano Micelles for the Repair of Infected Wounds.负载两亲性结构纳米胶束的ROS/pH双响应水凝胶敷料用于感染伤口修复
Int J Nanomedicine. 2025 Jun 23;20:8119-8142. doi: 10.2147/IJN.S522589. eCollection 2025.

引用本文的文献

1
Therapeutic Potential of PDA@CeO2 in Suppressing Hepatic Stellate Cell Activation and Preventing Liver Fibrosis.PDA@CeO2在抑制肝星状细胞活化和预防肝纤维化方面的治疗潜力
Int J Nanomedicine. 2025 Jul 15;20:9073-9091. doi: 10.2147/IJN.S521372. eCollection 2025.
2
Pathogenesis guided application of nanozymes in the treatment of inflammatory bowel disease.基于发病机制指导的纳米酶在炎症性肠病治疗中的应用
Mater Today Bio. 2025 Jun 21;33:102008. doi: 10.1016/j.mtbio.2025.102008. eCollection 2025 Aug.
3
Orally Administrated Inulin-Modified Nanozymes for CT-Guided IBD Theranostics.

本文引用的文献

1
Polydopamine-coated thalidomide nanocrystals promote DSS-induced murine colitis recovery through Macrophage M2 polarization together with the synergistic anti-inflammatory and anti-angiogenic effects.聚多巴胺包被的沙利度胺纳米晶体通过巨噬细胞M2极化以及协同的抗炎和抗血管生成作用促进葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎恢复。
Int J Pharm. 2023 Jan 5;630:122376. doi: 10.1016/j.ijpharm.2022.122376. Epub 2022 Nov 15.
2
Ceria Nanoenzyme-Based Hydrogel with Antiglycative and Antioxidative Performance for Infected Diabetic Wound Healing.基于二氧化铈纳米酶的具有抗糖基化和抗氧化性能的水凝胶用于感染性糖尿病伤口愈合
Small Methods. 2022 Nov;6(11):e2200949. doi: 10.1002/smtd.202200949. Epub 2022 Oct 6.
3
用于CT引导的炎症性肠病诊疗的口服菊粉修饰纳米酶
Int J Nanomedicine. 2025 Feb 18;20:2119-2131. doi: 10.2147/IJN.S497558. eCollection 2025.
4
Hollow cerium nanoparticles synthesized by one-step method for multienzyme activity to reduce colitis in mice.通过一步法合成的中空铈纳米颗粒具有多酶活性以减轻小鼠结肠炎。
World J Gastroenterol. 2025 Feb 7;31(5):98732. doi: 10.3748/wjg.v31.i5.98732.
5
Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease.用于炎症性肠病的纳米材料药物递送系统分类
Int J Nanomedicine. 2025 Feb 3;20:1383-1399. doi: 10.2147/IJN.S502546. eCollection 2025.
6
Mechanism and Application of Biomaterials Targeting Reactive Oxygen Species and Macrophages in Inflammation.炎症中靶向活性氧和巨噬细胞的生物材料的作用机制与应用
Int J Mol Sci. 2024 Dec 30;26(1):245. doi: 10.3390/ijms26010245.
7
Ligand-to-Metal Ratio Governs Radical-Scavenging Ability of Malate-Stabilised Ceria Nanoparticles.配体与金属的比例决定苹果酸稳定的二氧化铈纳米颗粒的自由基清除能力。
Nanomaterials (Basel). 2024 Nov 27;14(23):1908. doi: 10.3390/nano14231908.
8
Revolutionizing oral care: Reactive oxygen species (ROS)-Regulating biomaterials for combating infection and inflammation.口腔护理的变革：用于对抗感染和炎症的活性氧（ROS）调节生物材料。
Redox Biol. 2025 Feb;79:103451. doi: 10.1016/j.redox.2024.103451. Epub 2024 Nov 30.
9
Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy.恢复肠道屏障完整性：一种炎症性肠病的治疗方法。
J Inflamm Res. 2024 Aug 14;17:5389-5413. doi: 10.2147/JIR.S470520. eCollection 2024.
Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles.
肽修饰氧化铈纳米粒子的制备、表征及多种生物学特性
Biomolecules. 2022 Sep 10;12(9):1277. doi: 10.3390/biom12091277.
4
Enhanced Antioxidant Ability of PEG-Coated CeZrO-Based Nanofluids for Scavenging Hydroxyl Radicals.聚乙二醇包覆的铈锆基纳米流体清除羟基自由基的抗氧化能力增强
ACS Omega. 2022 Jun 21;7(26):22363-22376. doi: 10.1021/acsomega.2c01266. eCollection 2022 Jul 5.
5
Manipulation of Gut Microbiota as a Key Target for Crohn's Disease.肠道微生物群的调控作为克罗恩病的关键靶点
Front Med (Lausanne). 2022 Jun 16;9:887044. doi: 10.3389/fmed.2022.887044. eCollection 2022.
6
Nutraceuticals for the Treatment of IBD: Current Progress and Future Directions.用于治疗炎症性肠病的营养保健品：当前进展与未来方向
Front Nutr. 2022 Jun 6;9:794169. doi: 10.3389/fnut.2022.794169. eCollection 2022.
7
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.炎症性肠病：临床诊断与外科治疗概述。
Medicina (Kaunas). 2022 Apr 21;58(5):567. doi: 10.3390/medicina58050567.
8
Update on the epidemiology of inflammatory bowel disease in Asia: where are we now?亚洲炎症性肠病流行病学的最新情况：我们目前处于什么阶段？
Intest Res. 2022 Apr;20(2):159-164. doi: 10.5217/ir.2021.00115. Epub 2022 Apr 29.
9
Decorating Bacteria with Triple Immune Nanoactivators Generates Tumor-Resident Living Immunotherapeutics.用三重免疫纳米激活剂装饰细菌可产生肿瘤驻留的活体免疫疗法。
Angew Chem Int Ed Engl. 2022 Jul 4;61(27):e202202409. doi: 10.1002/anie.202202409. Epub 2022 May 9.
10
Excessive Apoptosis in Ulcerative Colitis: Crosstalk Between Apoptosis, ROS, ER Stress, and Intestinal Homeostasis.溃疡性结肠炎中的细胞凋亡过度：细胞凋亡、ROS、内质网应激与肠道内稳态的串扰。
Inflamm Bowel Dis. 2022 Mar 30;28(4):639-648. doi: 10.1093/ibd/izab277.