Chagas Priscilla Farias, Dos Santos Thais Barbosa, Dos Santos Trivino Gesiane, Bussadori Sandra Kalil, Duran Cinthya Cosme Gutierrez, Fernandes Kristianne Porta Santos, Cecatto Rebeca Boltes, Horliana Anna Carolina Ratto Tempestini, Mesquita-Ferrari Raquel Agnelli
Postgraduate Program in Biophotonics - Medicine, Universidade Nove de Julho, UNINOVE, São Paulo, São Paulo, Brazil.
Primary Care Coordination (CAP) Program Area 5.1 of Rio de Janeiro, Rio de Janeiro, Brazil.
Lasers Surg Med. 2025 Aug;57(6):457-465. doi: 10.1002/lsm.70037. Epub 2025 Jun 22.
Diabetic foot ulcers affect approximately 15% of individuals with diabetes, compromising their quality of life and placing an additional burden on the public health system.
This study aims to evaluate the effects of the antimicrobial photodynamic therapy (aPDT) in tissue repair through the analysis of two case studies involving individuals with diabetes-related foot lesions.
aPDT was performed using 1% methylene blue, a cluster of four red lasers (660 nm) with an average radiant power of 100 mW, and radiant energy per emitter of 6 J. The exposure time was 1 min, resulting in a total radiant energy per session of 24 J. Patients were evaluated on sessions 1, 3, 5, 10, and 30 days after the completion of treatment.
Using the Bates-Jensen Wound Assessment Tool (BWAT) scale as a tool to assess wound progression, Patient 1 had an initial score of 37 points, which reduced to 24 points by the end of treatment, resulting in a decrease of 13 points on the scale. Patient 2 started with 36 points and finished with 14 points, achieving complete healing.
Treatment led to improved wound quality, evidenced by a reduction in BWAT scores, a 74.9% decrease in wound area in patient 1 with consistent healing progress, and complete wound closure in patient 2. Although limited by its case-series design, this study contributes preliminary clinical evidence suggesting the potential benefits of antimicrobial photodynamic therapy (aPDT) in the management of diabetic foot ulcers and highlights the need for larger, controlled trials to validate its efficacy. In conclusion, aPDT was effective across all evaluated outcomes in these two reported cases.
NCT06416462 (initial release: 09/23).
糖尿病足溃疡影响约15%的糖尿病患者，损害他们的生活质量，并给公共卫生系统带来额外负担。
本研究旨在通过分析两个涉及糖尿病相关足部病变患者的病例研究，评估抗菌光动力疗法（aPDT）对组织修复的影响。
使用1%亚甲蓝、一束四个平均辐射功率为100 mW的红色激光（660 nm）以及每个发射器6 J的辐射能量进行aPDT治疗。照射时间为1分钟，每次治疗的总辐射能量为24 J。在治疗完成后的第1、3、5、10和30天对患者进行评估。
使用贝茨 - 詹森伤口评估工具（BWAT）量表作为评估伤口进展的工具，患者1初始评分为37分，治疗结束时降至24分，量表得分下降了13分。患者2开始时为36分，结束时为14分，实现了完全愈合。
治疗导致伤口质量改善，表现为BWAT评分降低，患者1伤口面积减少74.9%且愈合进展持续，患者2伤口完全闭合。尽管本研究受限于其病例系列设计，但提供了初步临床证据，表明抗菌光动力疗法（aPDT）在糖尿病足溃疡管理中的潜在益处，并强调需要进行更大规模的对照试验来验证其疗效。总之，在这两个报告病例中，aPDT在所有评估结果方面均有效。
NCT06416462（首次发布：09/23）
