用亚甲蓝光动力疗法治疗感染伤口：一种有效且安全的治疗方法。

Treatment of infected wounds with methylene blue photodynamic therapy: An effective and safe treatment method.

作者信息

Shen Xiaoxiao, Dong Liwen, He Xuan, Zhao Chuanqi, Zhang Wanqi, Li Xinying, Lu Yuangang

机构信息

Department of Plastic & Cosmetic Surgery, Daping Hospital, Amy Medical University, Chongqing 400042, PR China.

出版信息

Photodiagnosis Photodyn Ther. 2020 Dec;32:102051. doi: 10.1016/j.pdpdt.2020.102051. Epub 2020 Oct 12.

DOI:10.1016/j.pdpdt.2020.102051

PMID:33059110

Abstract

BACKGROUND

Bacterial resistance is a problem during the process of healing of infected wounds. As a therapy, photodynamic therapy (PDT) has broad-spectral antibacterial activity and non-selective action, which makes it possible to deal with antibiotic resistance.. Methylene blue is a commonly used medicine, but it is rarely used in clinical practice as a photosensitizer. The effect of methylene blue photodynamic therapy (MB-PDT) on infected wounds remains unclear. Our study aims to evaluate the safety and efficacy of MB-PDT on infected wounds.

METHODS

In this study, 5 patients with infected wounds were included, all of them were treated with MB-PDT by using the red LED which irradiated the wounds directly (635 nm, 120 J/cm2, 100 mW/cm2). The frequency and course of treatment were determined by the severity of the wound.

RESULTS

After an average of 4 PDT session, infected wounds of all the patients healed.. The treatment also showed an excellent cosmetic effect. According to the follow-up periods of patients ranged from 3 to 12 months, there were no recurrences and side effects.

CONCLUSIONS

MB-PDT has a great healing effect on infected wounds, and it is a safe, cheap and active clinical therapy.

摘要

背景

细菌耐药性是感染伤口愈合过程中的一个问题。作为一种治疗方法，光动力疗法（PDT）具有广谱抗菌活性和非选择性作用，这使得它有可能应对抗生素耐药性。亚甲蓝是一种常用药物，但作为光敏剂在临床实践中很少使用。亚甲蓝光动力疗法（MB-PDT）对感染伤口的效果仍不清楚。我们的研究旨在评估MB-PDT对感染伤口的安全性和有效性。