Shen Xiaoxiao, Dong Liwen, He Xuan, Zhao Chuanqi, Zhang Wanqi, Li Xinying, Lu Yuangang
Department of Plastic & Cosmetic Surgery, Daping Hospital, Amy Medical University, Chongqing 400042, PR China.
Department of Plastic & Cosmetic Surgery, Daping Hospital, Amy Medical University, Chongqing 400042, PR China.
Photodiagnosis Photodyn Ther. 2020 Dec;32:102051. doi: 10.1016/j.pdpdt.2020.102051. Epub 2020 Oct 12.
Bacterial resistance is a problem during the process of healing of infected wounds. As a therapy, photodynamic therapy (PDT) has broad-spectral antibacterial activity and non-selective action, which makes it possible to deal with antibiotic resistance.. Methylene blue is a commonly used medicine, but it is rarely used in clinical practice as a photosensitizer. The effect of methylene blue photodynamic therapy (MB-PDT) on infected wounds remains unclear. Our study aims to evaluate the safety and efficacy of MB-PDT on infected wounds.
In this study, 5 patients with infected wounds were included, all of them were treated with MB-PDT by using the red LED which irradiated the wounds directly (635 nm, 120 J/cm2, 100 mW/cm2). The frequency and course of treatment were determined by the severity of the wound.
After an average of 4 PDT session, infected wounds of all the patients healed.. The treatment also showed an excellent cosmetic effect. According to the follow-up periods of patients ranged from 3 to 12 months, there were no recurrences and side effects.
MB-PDT has a great healing effect on infected wounds, and it is a safe, cheap and active clinical therapy.
细菌耐药性是感染伤口愈合过程中的一个问题。作为一种治疗方法，光动力疗法（PDT）具有广谱抗菌活性和非选择性作用，这使得它有可能应对抗生素耐药性。亚甲蓝是一种常用药物，但作为光敏剂在临床实践中很少使用。亚甲蓝光动力疗法（MB-PDT）对感染伤口的效果仍不清楚。我们的研究旨在评估MB-PDT对感染伤口的安全性和有效性。
本研究纳入了5例感染伤口患者，所有患者均采用红色发光二极管直接照射伤口的方式进行MB-PDT治疗（635nm，120J/cm²，100mW/cm²）。治疗频率和疗程根据伤口严重程度确定。
平均经过4次光动力治疗后，所有患者的感染伤口均愈合。治疗还显示出良好的美容效果。根据患者3至12个月的随访期，无复发及副作用。
MB-PDT对感染伤口有很好的愈合效果，是一种安全、廉价且有效的临床治疗方法。
