Beas-Zárate C, Arauz-Contreras J, Velazquez A, Feria-Velasco A
Gen Pharmacol. 1985;16(5):489-93. doi: 10.1016/0306-3623(85)90009-6.
Norepinephrine (NE) and dopamine (DA) levels in various brain regions were measured in a model of experimentally produced convulsions by monosodium L-glutamate (MSG) administration to adult rats. Stress by injection of all solutions produced a 60% decrease in NE level in forebrain, recovering its basal value at 15 min after injection. A significant reduction of brain NE and DA levels of MSG-injected animals was found in the preconvulsive stage, particularly in the forebrain. No significant variations in catecholamine levels were seen in brain stem and cerebellum as a result of MSG injection. It is suggested that the changes found in endogenous catecholamine concentration in the forebrain may play a physiological role in the mechanisms of production of convulsions in the MSG model.
通过向成年大鼠注射L-谷氨酸单钠（MSG）建立实验性惊厥模型，测量了各个脑区的去甲肾上腺素（NE）和多巴胺（DA）水平。注射所有溶液所产生的应激使前脑NE水平降低了60%，在注射后15分钟恢复到基础值。在惊厥前期，发现注射MSG的动物脑内NE和DA水平显著降低，尤其是在前脑。注射MSG后，脑干和小脑的儿茶酚胺水平未见明显变化。提示前脑内源性儿茶酚胺浓度的变化可能在MSG模型惊厥产生机制中发挥生理作用。
