Villarroya F, Mampel T, Herrera E
Gen Pharmacol. 1985;16(5):537-40. doi: 10.1016/0306-3623(85)90020-5.
Plasma ethanol concentration 3 hr after its oral administration (3 g/kg body wt) did not differ in 20 day pregnant rats with virgin controls, and in both groups values were higher when studied after 24 hr fasted than when fed. In fed animals, blood glucose and liver glycogen concentrations were lower in pregnant than in virgin rats, whereas ethanol intake in both groups enhanced blood glucose levels, it reduced liver glycogen content only in virgins. In fetuses, maternal ethanol intake enhanced blood glucose levels. In fasted animals, ethanol intake decreased blood glucose levels in pregnant and virgin animals but did not affect these levels in fetuses. Ethanol intake enhanced beta-hydroxybutyrate/acetoacetate ratio similarly in blood of pregnant and virgin rats when either fed or fasted, and it produced the same change in fetuses from fasted mothers. Results indicate that the metabolic response to acute ethanol does not differ between pregnant and non-pregnant animals, and it is proposed that fetuses passively follow the metabolic changes occurring in their mothers after receiving ethanol.
口服乙醇（3克/千克体重）3小时后，怀孕20天的大鼠血浆乙醇浓度与未孕对照大鼠并无差异。两组大鼠在禁食24小时后进行检测时的乙醇浓度均高于进食后。在进食的动物中，怀孕大鼠的血糖和肝糖原浓度低于未孕大鼠，而两组大鼠摄入乙醇后血糖水平均升高，只有未孕大鼠的肝糖原含量降低。在胎儿方面，母体摄入乙醇会提高血糖水平。在禁食的动物中，摄入乙醇会降低怀孕大鼠和未孕大鼠的血糖水平，但对胎儿的血糖水平没有影响。无论进食还是禁食，怀孕大鼠和未孕大鼠摄入乙醇后血液中β-羟基丁酸/乙酰乙酸的比率均会以相似的幅度升高，且禁食母鼠所产胎儿也会出现同样的变化。结果表明，怀孕和未孕动物对急性乙醇的代谢反应并无差异，并且推测胎儿在摄入乙醇后会被动地跟随母体发生代谢变化。
