Villarroya F, Mampel T
Gen Pharmacol. 1985;16(6):591-6. doi: 10.1016/0306-3623(85)90148-x.
The effects of chronic ethanol treatment on intravenous glucose tolerance and insulin response in non-pregnant and pregnant rats were studied. Basal circulating glucose, insulin, and ketone bodies levels were also determined during the treatment. Basal blood glucose concentration did not change during the ethanol treatment whereas plasma insulin levels were lower at the beginning of gestation and at the 15 and 18 days of pregnancy in ethanol-treated rats. Blood beta-OH-butyrate levels were higher and acetoacetate concentrations unchanged during the ethanol treatment, resulting in augmented beta-OH-butyrate/acetoacetate ratio. Intravenous glucose tolerance was not modified in ethanol-treated rats whilst the associated insulin response was lower in both non-pregnant and pregnant ethanol-treated rats. Data show that ethanol treatment during pregnancy alters glucose-insulin relationships despite being associated with unchanged maternal glycemia.
研究了慢性乙醇处理对未怀孕和怀孕大鼠静脉葡萄糖耐量及胰岛素反应的影响。在处理过程中还测定了基础循环葡萄糖、胰岛素和酮体水平。乙醇处理期间基础血糖浓度未发生变化，而乙醇处理的大鼠在妊娠开始时以及妊娠第15天和第18天时血浆胰岛素水平较低。乙醇处理期间血液β-羟基丁酸水平较高，乙酰乙酸浓度未变，导致β-羟基丁酸/乙酰乙酸比值升高。乙醇处理的大鼠静脉葡萄糖耐量未改变，而未怀孕和怀孕的乙醇处理大鼠的相关胰岛素反应均较低。数据表明，孕期乙醇处理会改变葡萄糖-胰岛素关系，尽管母体血糖未变。
