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小鼠下颌骨形态的遗传学

Genetics of mandible form in the mouse.

作者信息

Atchley W R, Plummer A A, Riska B

出版信息

Genetics. 1985 Nov;111(3):555-77. doi: 10.1093/genetics/111.3.555.

Abstract

The underlying determination of phenotypic variability and covariability is described for 14 traits that define the morphological size and shape of the mature mouse mandible. Variability is partitioned into components due to direct additive and dominance genetic effects, indirect maternal additive genetic effects, genetic covariance between direct additive and indirect maternal additive effects and common and residual environmental effects. Multivariate analyses of the dimensionality of genetic variability indicate several complex and independent genetic components underlie the morphological form of the mandible. The multidimensional nature of the genetic components suggests a complex picture with regard to the consequences of selection on mandibular form.

摘要

针对定义成熟小鼠下颌骨形态大小和形状的14个性状,描述了表型变异性和协变性的潜在决定因素。变异性被划分为直接加性和显性遗传效应、间接母体加性遗传效应、直接加性与间接母体加性效应之间的遗传协方差以及共同环境效应和残余环境效应所导致的成分。对遗传变异性维度的多变量分析表明,下颌骨形态形式背后存在几个复杂且独立的遗传成分。遗传成分的多维性质表明,在选择对下颌骨形态的影响方面呈现出一幅复杂的图景。

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