Gus'kov E P, Shkurat T P
Genetika. 1985 Aug;21(8):1361-7.
High pressure of oxygen induces chromosomal rearrangements in metaphases of human peripherical blood cells treated in vitro. An increase in the percentage of rearrangements was detected in the third mitosis, due mainly to chromatid breaks. The data of cytogenetical analysis of lymphocytes of human blood treated in vivo at 3 ata for 30 min are presented. A differential character of distribution spectrum of chromosomal aberrations induced after in vivo and in vitro treatment was noted. Some unusual alterations in chromosome morphology are described, namely, solid, not stained clear lense-like bodies surrounded by chromatin and localised in the long arm of chromatids.
体外处理的人外周血细胞中期，高压氧可诱导染色体重排。在第三次有丝分裂中检测到重排百分比增加，主要是由于染色单体断裂。本文给出了在3个绝对大气压下体内处理30分钟的人血淋巴细胞的细胞遗传学分析数据。注意到体内和体外处理后诱导的染色体畸变分布谱具有差异特征。描述了染色体形态的一些异常变化，即由染色质包围并位于染色单体长臂上的坚实、未清晰染色的透镜样小体。
