Liebscher Maxie, Laubacher Claire, Imhoff-Smith Theodore P, Birn Rasmus M, Klaus Danika R, Frye Corrina J, Busse William W, Rosenkranz Melissa A
Center for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin.
German Center for Neurodegenerative Diseases, Dresden, Germany.
Biol Psychiatry Glob Open Sci. 2025 May 8;5(5):100527. doi: 10.1016/j.bpsgos.2025.100527. eCollection 2025 Sep.
Asthma and depression frequently co-occur, potentially worsening each other's symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms.
Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex.
Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate-corrected [ ] = .004) and betweenness centrality (β = 0.10, = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, = .010; left: β = 0.23, = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = -0.10, = .038), which correlated with depressive symptoms.
Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN's critical role in network switching and its vulnerability to inflammation in asthma-depression connection.
哮喘和抑郁症经常同时出现，可能会使彼此的症状恶化。突显网络（SN）可能在这种关联中起关键作用，但三重网络理论中概述的默认模式网络（DMN）和额顶网络（FPN）在哮喘与抑郁症的关联中所起的作用仍不清楚。这项纵向研究调查了哮喘患者在这三个网络内部和之间的图论指标的前后变化，以及这些变化与抑郁症状的关系。
24名哮喘患者在节段性过敏原激发前后接受了功能磁共振成像扫描。使用贝克抑郁量表在基线时评估抑郁症状。使用感兴趣区域（ROI）到ROI分析来分析图论指标的变化，并对性别进行了控制。
过敏原激发导致网络属性发生变化。网络内分析显示，后扣带回皮质（DMN）的度中心性降低（β = 0.50，错误发现率校正后P = 0.004）和介数中心性降低（β = 0.10，P = 0.025），前扣带回皮质（SN）的度中心性降低，这与抑郁症状相关（β = 0.05，P = 0.017）。网络间分析显示，在SN-DMN相互作用期间，双侧外侧顶叶的接近中心性降低（右侧：β = 0.23，P = 0.010；左侧：β = 0.23，P = 0.013），在SN-FPN相互作用期间，左侧后顶叶皮质的度中心性增加（β = -0.10，P = 0.038），这与抑郁症状相关。
过敏原激发会改变静息态网络内部和之间的图论指标，这些变化与抑郁症状有关。研究结果突出了SN在网络切换中的关键作用及其在哮喘-抑郁症关联中对炎症的易感性。
