C57BL/6小鼠及不同年龄的a小鼠中的葡萄糖磷酸异构酶活性。

Glucose phosphate isomerase activity in C57BL/6 and a mice of different ages.

作者信息

Warner C M, Briggs C J, Balinsky D, Meyer T E

出版信息

Gerontology. 1985;31(5):315-20. doi: 10.1159/000212715.

Abstract

Glucose phosphate isomerase (GPI) enzyme activity was measured in two strains of mice, A/HeNNial (Gpi-1a) and C57BL/6NNia1 (Gpi-1b). Seven solid tissues (muscle, brain, heart, kidney, liver, lung, spleen) and three cell types (peripheral blood lymphocytes, spleen lymphocytes, erythrocytes) were analyzed for GPI activity in mice from 6 to 36 months of age. No major changes in enzyme activity with age were found. The most striking observation was that A/HeNNial mice showed a significantly higher GPI activity than C57BL/6NNia1 mice in four of the solid tissues (muscle, heart, kidney, spleen) and two of the cell types (peripheral blood lymphocytes, erythrocytes) analyzed.

摘要

在两种品系的小鼠，即A/HeNNial（Gpi-1a）和C57BL/6NNia1（Gpi-1b）中测量了葡萄糖磷酸异构酶（GPI）的酶活性。对6至36月龄小鼠的七种实体组织（肌肉、脑、心脏、肾脏、肝脏、肺、脾脏）和三种细胞类型（外周血淋巴细胞、脾脏淋巴细胞、红细胞）进行了GPI活性分析。未发现酶活性随年龄有重大变化。最显著的观察结果是，在分析的四种实体组织（肌肉、心脏、肾脏、脾脏）和两种细胞类型（外周血淋巴细胞、红细胞）中，A/HeNNial小鼠的GPI活性显著高于C57BL/6NNia1小鼠。