Gibson P H
Gerontology. 1985;31(5):321-4. doi: 10.1159/000212716.
Four neocortical regions (frontal, parietal, temporal, occipital) of 44 cases were impregnated by a silver stain to show neuritic plaques and stained with Congo red to show amyloid plaques. In 11 cases with large numbers of argentophilic plaques these plaques decreased significantly with age while the reverse appeared to be true for the congophilic plaques. In the remaining 34 cases which had few argentophilic plaques the numbers of congophilic plaques increased significantly with age in the parietal and occipital regions. These results suggest that the neuritic component of senile plaques precedes the amyloid cores in their pathogenesis although a causative relationship is not implied.
对44例患者的四个新皮质区域（额叶、顶叶、颞叶、枕叶）进行银染以显示神经炎性斑块，并用刚果红染色以显示淀粉样斑块。在11例有大量嗜银性斑块的病例中，这些斑块随年龄增长显著减少，而嗜刚果红性斑块则相反。在其余34例嗜银性斑块较少的病例中，顶叶和枕叶区域的嗜刚果红性斑块数量随年龄增长显著增加。这些结果表明，老年斑的神经炎性成分在发病机制上先于淀粉样核心，尽管并未暗示存在因果关系。
