Zhao Zelda Ziyi, Shan Wenwen, Guo Lifeng, Chu Chun Hung, Zhang Jing
Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Key Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University, Hefei, China.
Front Oral Health. 2025 Jun 6;6:1573863. doi: 10.3389/froh.2025.1573863. eCollection 2025.
, a major periodontal pathogen, interacts with other oral microbes through quorum sensing, enhancing its growth and virulence, which contributes to periodontitis. This scoping review aims to examine the role of quorum sensing in the interactions between and other oral microbial species.
Two independent researchers conducted a systematic search using the keywords {[(quorum sensing) OR QS] AND [() OR ]} for English publications prior to 2025 from Medline, Scopus, and Web of Science databases. They screened titles and abstracts, retrieving full texts of original studies to identify key concepts and findings regarding the quorum sensing of in oral microbial ecosystems.
A total of 205 publications were identified, of which 26 were included in the review. These studies demonstrated quorum sensing of and other bacteria through signal molecules Autoinducer-1 and Autoinducer-2. Autoinducer-1 enhances the pathogenicity of , facilitating its integration into complex oral microbial communities. Autoinducer-2 fosters cooperative or competitive relationships between and other periodontal pathogens, modifying the structure of oral biofilms. Additionally, researchers are studying the use of quorum sensing inhibitors to reduce the virulence of for managing periodontitis and restoring microbial balance in the oral cavity.
Quorum sensing enhances the pathogenicity of in the oral environment. Through the modulation of Autoinducer-1 and Autoinducer-2, quorum sensing regulates interactions between and other oral microbes. This study demonstrates the need for further research into quorum sensing-targeted interventions in periodontal therapy.
作为一种主要的牙周病原体，通过群体感应与其他口腔微生物相互作用，增强其生长和毒力，这会导致牙周炎。本综述旨在研究群体感应在与其他口腔微生物物种相互作用中的作用。
两名独立研究人员使用关键词{[(群体感应)或QS] AND [()或]}对Medline、Scopus和Web of Science数据库中2025年之前的英文出版物进行系统检索。他们筛选标题和摘要，检索原始研究的全文，以确定关于在口腔微生物生态系统中群体感应的关键概念和发现。
共识别出205篇出版物，其中26篇纳入综述。这些研究通过信号分子自诱导物-1和自诱导物-2证明了和其他细菌的群体感应。自诱导物-1增强了的致病性，促进其融入复杂的口腔微生物群落。自诱导物-2促进了与其他牙周病原体之间的合作或竞争关系，改变了口腔生物膜的结构。此外，研究人员正在研究使用群体感应抑制剂来降低的毒力，以治疗牙周炎并恢复口腔中的微生物平衡。
群体感应增强了在口腔环境中的致病性。通过调节自诱导物-1和自诱导物-2，群体感应调节了与其他口腔微生物之间的相互作用。本研究表明需要进一步研究针对群体感应的牙周治疗干预措施。
