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糖尿病Wistar大鼠牙周细菌的研究：评估香芹酚和厚朴酚水凝胶的抗炎作用

Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels.

作者信息

Potra Cicalău Georgiana Ioana, Marcu Olivia Andreea, Ghitea Timea Claudia, Ciavoi Gabriela, Iurcov Raluca Cristina, Beiusanu Corina, Trifan Daniela Florina, Vicaș Laura Grațiela, Ganea Mariana

机构信息

Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania.

Department of Preclinics, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania.

出版信息

Biomedicines. 2024 Jun 28;12(7):1445. doi: 10.3390/biomedicines12071445.

DOI:10.3390/biomedicines12071445
PMID:39062018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274435/
Abstract

Periodontal disease and diabetes often co-occur; both are characterized by chronic inflammation. This study aimed to investigate the anti-inflammatory effects of carvacrol and magnolol when incorporated into a periodontal hydrogel and topically applied to Wistar rats with diabetes-associated periodontal disease. Forty male albino Wistar rats were divided into four groups: PD (induced diabetes and periodontitis), PDC (induced diabetes and periodontitis treated with carvacrol), PDM (induced diabetes and periodontitis treated with magnolol), and PDCM (induced diabetes and periodontitis treated with both carvacrol and magnolol). Post treatment, gingival tissue samples were collected to measure levels of the pro-inflammatory cytokines IL-6 and TNF-α. The PDCM group exhibited significantly lower levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) compared to the PD group. The combined application of a periodontal hydrogel containing carvacrol and magnolol may significantly reduce gingival inflammation in rats with diabetes-associated periodontal disease.

摘要

牙周病和糖尿病常常同时出现；两者均以慢性炎症为特征。本研究旨在探讨香芹酚和厚朴酚加入牙周水凝胶并局部应用于患糖尿病相关性牙周病的Wistar大鼠时的抗炎作用。40只雄性白化Wistar大鼠被分为四组：PD组（诱导糖尿病和牙周炎）、PDC组（诱导糖尿病和牙周炎并接受香芹酚治疗）、PDM组（诱导糖尿病和牙周炎并接受厚朴酚治疗）和PDCM组（诱导糖尿病和牙周炎并接受香芹酚和厚朴酚联合治疗）。治疗后，收集牙龈组织样本以测量促炎细胞因子IL-6和TNF-α的水平。与PD组相比，PDCM组的白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）水平显著降低。含有香芹酚和厚朴酚的牙周水凝胶联合应用可能显著减轻患糖尿病相关性牙周病大鼠的牙龈炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/b5ce6072686f/biomedicines-12-01445-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/f3b52a1e29f0/biomedicines-12-01445-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/912926dabae2/biomedicines-12-01445-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/319616ad69f2/biomedicines-12-01445-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/b5ce6072686f/biomedicines-12-01445-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/f3b52a1e29f0/biomedicines-12-01445-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/912926dabae2/biomedicines-12-01445-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/319616ad69f2/biomedicines-12-01445-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84a/11274435/b5ce6072686f/biomedicines-12-01445-g004.jpg

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