Cai Zhao, Dai Wei-De, Cai Xiong-Wei
Department of Ultrasound, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China.
Department of Gynecology, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing 410013, China.
World J Gastrointest Oncol. 2025 Jun 15;17(6):100010. doi: 10.4251/wjgo.v17.i6.100010.
In this article, we critically appraise the study by Wu , which investigated the prognostic value of preoperative inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis. This retrospective cohort study included 133 patients. The findings indicate that patients with high neutrophil-to-lymphocyte ratios (NLRs) or lower hemoglobin (Hb) levels have significantly shorter overall survival (OS) than those with lower NLRs or normal Hb levels, respectively. Furthermore, age, carbohydrate antigen 199 levels, the NLR, Hb, and the peritoneal cancer index were identified as independent prognostic factors for OS. A nomogram was subsequently developed, demonstrating its ability to accurately predict the OS of colorectal cancer patients with peritoneal metastasis. This study introduces a potentially valuable prognostic tool for these patients. However, further validation in multicenter cohorts is needed to confirm its clinical applicability, to assess its limitations, and to elucidate the underlying mechanism of these identified biomarkers.
在本文中，我们对吴的一项研究进行了批判性评价，该研究调查了术前炎症和营养标志物对结直肠癌腹膜转移患者的预后价值。这项回顾性队列研究纳入了133例患者。研究结果表明，中性粒细胞与淋巴细胞比值（NLR）高或血红蛋白（Hb）水平低的患者，其总生存期（OS）分别显著短于NLR低或Hb水平正常的患者。此外，年龄、糖类抗原199水平、NLR、Hb和腹膜癌指数被确定为OS的独立预后因素。随后制定了一个列线图，证明其能够准确预测结直肠癌腹膜转移患者的OS。这项研究为这些患者引入了一种潜在有价值的预后工具。然而，需要在多中心队列中进行进一步验证，以确认其临床适用性，评估其局限性，并阐明这些已确定生物标志物的潜在机制。
