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自然光照:一种可控的光照环境,用于研究光照对自由活动大鼠行为和认知的影响。

Naturalight: A controlled illuminated environment to study light exposure impact on behavior and cognition in freely moving rats.

作者信息

Hecquet Christophe, Etcheberry Maylis, Ravel Nadine, Litaudon Philippe, Pain Frédéric

机构信息

Université Paris-Saclay, Institut d'Optique Graduate School, CNRS, Laboratoire Charles Fabry, 91127 Palaiseau, France.

Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, CMO team, Centre Hospitalier Le Vinatier - Bâtiment 462, Neurocampus Michel Jouvet - 95 Bd Pinel, 69675 Bron Cedex, France.

出版信息

HardwareX. 2025 Jun 3;23:e00662. doi: 10.1016/j.ohx.2025.e00662. eCollection 2025 Sep.

Abstract

In humans, scientific studies have shown that the increased use of screens at night and prolonged exposure to artificial light, particularly blue light, can significantly disrupt the organization of sleep-wake cycles and the functions that depend on them like memory. In rodents, moderate and even weak exposures to light have been shown to have various and either detrimental or beneficial effects on circadian rhythms, behavior, cognition. Yet, scattered and sometimes opposite effects are reported in the literature, which is largely attributed to differences in experimental conditions, especially on the definition and evaluation of the actual dose of light received. To address this issue, we have built an enclosure with controlled and characterized illumination. It can be used as a standalone experimental environment or eventually connected to naturalistic environment where several animals live constantly and interact freely within several housing modules, including the controlled illumination one.

摘要

在人类中,科学研究表明,夜间屏幕使用增加以及长时间暴露于人造光,尤其是蓝光,会显著扰乱睡眠-觉醒周期的节律以及依赖这些节律的功能,如记忆。在啮齿动物中,适度甚至微弱的光照暴露已被证明对昼夜节律、行为、认知有各种不同的影响,这些影响既有有害的,也有有益的。然而,文献中报道的影响分散,有时甚至相互矛盾,这在很大程度上归因于实验条件的差异,尤其是在实际接受光照剂量的定义和评估方面。为了解决这个问题,我们构建了一个具有可控且特征明确的照明环境的 enclosure。它既可以用作独立的实验环境,也可以最终连接到自然环境,在自然环境中,几只动物在几个居住模块(包括可控照明模块)中持续生活并自由互动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16ae/12179621/adca1650a018/ga1.jpg

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