Wilkins J S, Swartz M L, Phillips R W
J Prosthet Dent. 1977 Jun;37(6):666-73. doi: 10.1016/0022-3913(77)90217-7.
A pilot study was conducted employing the Macaca speciosa monkey to determine the retention and sealing ability of pit and fissure sealants in vivo. Several problems were encountered in the use of this animal model for this type of evaluation. Without doubt, the conditions to which the sealants were subjected in the monkey were more rigorous than those found in man. This is attested to by the lower rate of retention of sealants as compared to that found in studies on human beings. To increase the usefulness of animal studies of this type, additional research should be done to better establish the correlation between the behavior of sealants in the animal and in man. Nevertheless, certain pertinent observations were made, one of which is that in some instances where the sealant was retained on the teeth, the sealant-tooth interface was readily penetrated by an isotope solution.
采用戴帽叶猴进行了一项初步研究，以确定窝沟封闭剂在体内的保留率和封闭能力。在使用这种动物模型进行此类评估时遇到了几个问题。毫无疑问，封闭剂在猴子体内所经受的条件比在人类中更为苛刻。与人类研究相比，封闭剂的保留率较低就证明了这一点。为了提高此类动物研究的实用性，应开展更多研究，以更好地确定封闭剂在动物和人类中的行为之间的相关性。然而，还是得出了一些相关观察结果，其中之一是，在某些封闭剂保留在牙齿上的情况下，同位素溶液很容易穿透封闭剂与牙齿的界面。
