Do Tuyet-Nhi, Lee Po-Hsin, Tsai Tsung-Lin, Wu Ping-Ching
Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan 701, Taiwan.
Meet Tec. Co., Ltd., Tainan 710, Taiwan.
ACS Omega. 2025 Jun 3;10(23):24422-24431. doi: 10.1021/acsomega.5c00665. eCollection 2025 Jun 17.
The rise in antimicrobial resistance (AMR) pathogens necessitates innovative approaches for infection control, particularly in medical device applications. Moreover, simultaneously ensuring sustained antimicrobial activity in biomaterials and minimizing potential resistance development remain critical aspects that lack new strategies. This study presents the development and application of an innovative antimicrobial agent, that is, a multifunctional polysaccharide-encapsulated Lauraceae extract complex (PLEC) coating designed to enhance the antimicrobial efficacy and compatibility of polypropylene surfaces. The study findings indicate that the PLEC coating has potent antibacterial and antifungal characteristics, preventing a wide range of infections. A comprehensive analysis revealed significant reductions in bacterial colonies, including colonies of Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), Gram-positive bacteria (Staphylococcus aureus and Streptococcus mitis), and various fungal strains. Moreover, cytotoxicity evaluations confirm the nontoxic nature of the coatings, ensuring their safety for medical use. This study demonstrates that multifunctional antimicrobial PLEC coatings offer a significant advancement in infection control strategies, providing an effective solution to the growing problem of AMR. The developed approach can be beneficial to the healthcare industry and society by reducing infection risks and treatment costs, ultimately improving clinical effectiveness and enhancing the efficacy of infection control measures in medical applications.
抗菌耐药性（AMR）病原体的增加需要创新的感染控制方法，尤其是在医疗设备应用中。此外，同时确保生物材料中持续的抗菌活性并最大限度地减少潜在的耐药性发展，仍然是缺乏新策略的关键方面。本研究介绍了一种创新抗菌剂的开发和应用，即一种多功能多糖包裹的樟科提取物复合物（PLEC）涂层，旨在提高聚丙烯表面的抗菌效果和相容性。研究结果表明，PLEC涂层具有强大的抗菌和抗真菌特性，可预防多种感染。全面分析显示细菌菌落数量显著减少，包括革兰氏阴性菌（大肠杆菌和铜绿假单胞菌）、革兰氏阳性菌（金黄色葡萄球菌和缓症链球菌）以及各种真菌菌株的菌落。此外，细胞毒性评估证实了涂层的无毒性质，确保了其医疗使用的安全性。本研究表明，多功能抗菌PLEC涂层在感染控制策略方面取得了重大进展，为日益严重的AMR问题提供了有效的解决方案。所开发的方法通过降低感染风险和治疗成本，最终提高临床效果并增强医疗应用中感染控制措施的效果，对医疗行业和社会有益。
