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免疫接种后的不良反应与疫苗犹豫:印度南部某地区的一项定性研究

Adverse Effects Following Immunisation and Vaccine Hesitancy: A Qualitative Study in a South Indian District.

作者信息

Gopalan Retheesh Babu, Babu Bontha V, Sarma S Krishna, John Rooth P

机构信息

ICMR-National Institute of Virology, Kerala Unit, Alappuzha, 688 005, India.

Division of Socio-Behavioural, Health Systems & Implementation Research, Indian Council of Medical Research, New Delhi, 110 029, India.

出版信息

Drug Healthc Patient Saf. 2025 Jun 16;17:145-156. doi: 10.2147/DHPS.S515064. eCollection 2025.

Abstract

BACKGROUND

Parental perceptions and concerns about vaccine safety and 'adverse effects following immunisation' (AEFI) are the reasons for vaccine hesitancy. This study aimed to understand how these vaccine-related concerns have become significant determinants of vaccine decision-making among non-vaccinating parents in the Alappuzha district of Kerala, India. The healthcare providers' views in this regard are also reported.

METHODS

This is a qualitative study. In-depth interviews were conducted with informants from 110 households having non-immunised/partly-immunised children. In addition, 18 healthcare providers were interviewed. Thematic analysis using the reflective thematic method was carried out.

RESULTS

Parents reported incidences of minor events of AEFI and are hesitant to continue vaccination in circumstances when children need medical treatment. AEFI incidents within the family have seriously hampered the trust in vaccines. Parents have concerns about multiple vaccinations and have misconceptions about the content of vaccines. Other concerns that lead to hesitancy are vaccine-related infertility, polio infection after polio vaccination and autism due to vaccination. Healthcare providers reported that there were no serious incidents that needed hospitalisation. Health workers opined that informing parents about AEFIs and preparing them is better.

CONCLUSION

The study reported that AEFIs are a barrier to vaccine acceptance. It warrants the need to build trust in vaccines and the vaccination process. Transparent communication with the beneficiaries is crucial. AEFI monitoring and reporting should be an essential component of efforts to minimise vaccination hesitancy.

摘要

背景

父母对疫苗安全性及“免疫接种后不良反应”(AEFI)的认知和担忧是疫苗犹豫的原因。本研究旨在了解这些与疫苗相关的担忧如何成为印度喀拉拉邦阿拉普扎县未接种疫苗的父母做出疫苗决策的重要决定因素。同时也报告了医疗保健提供者在这方面的观点。

方法

这是一项定性研究。对来自110个有未接种/部分接种儿童家庭的信息提供者进行了深入访谈。此外,还采访了18名医疗保健提供者。采用反思性主题方法进行了主题分析。

结果

父母报告了AEFI的轻微事件发生率,并且在孩子需要医疗治疗的情况下,他们对继续接种疫苗犹豫不决。家庭内的AEFI事件严重损害了对疫苗的信任。父母对多次接种疫苗存在担忧,并且对疫苗的成分存在误解。导致犹豫的其他担忧包括疫苗相关的不孕症、脊髓灰质炎疫苗接种后的脊髓灰质炎感染以及接种疫苗导致的自闭症。医疗保健提供者报告称没有需要住院治疗的严重事件。卫生工作者认为,向父母通报AEFI并让他们做好准备更好。

结论

该研究报告称,AEFI是疫苗接受度的一个障碍。这就需要在疫苗和接种过程中建立信任。与受益者进行透明沟通至关重要。AEFI监测和报告应成为尽量减少疫苗犹豫努力的重要组成部分。

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