Emerman J T, Leahy M, Gout P W, Bruchovsky N
Horm Metab Res. 1985 Aug;17(8):421-4. doi: 10.1055/s-2007-1013563.
The concentrations of growth hormone (GH) and prolactin (PRL) in the serum of 42 breast cancer patients were determined by radioimmunoassay (RIA). Forty percent of the patients had elevated GH levels while only 17% had elevated PRL levels. These findings suggest a relationship between GH and breast cancer; a weaker correlation exists between PRL and this malignancy. In addition, total lactogens in the serum were measured by a bioassay (BA). The BA/RIA (GH + PRL) ratio was greater in the breast cancer patients than the controls, indicating that variant forms of the hormones with higher than normal biological activity might be present.
采用放射免疫分析法（RIA）测定了42例乳腺癌患者血清中生长激素（GH）和催乳素（PRL）的浓度。40%的患者GH水平升高，而只有17%的患者PRL水平升高。这些发现提示GH与乳腺癌之间存在关联；PRL与这种恶性肿瘤之间的相关性较弱。此外，通过生物测定法（BA）测量血清中的总催乳素。乳腺癌患者的BA/RIA（GH + PRL）比值高于对照组，表明可能存在生物活性高于正常水平的激素变体形式。
