Zhao He, Xia Yun, Su Fei, Chen Liuqing, Hu Bin
Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, 430022, China.
Hubei Province & Key Laboratory of Skin Infection and Immunity, Wuhan No. 1 Hospital, Wuhan, 430022, China.
Discov Oncol. 2025 Jun 23;16(1):1185. doi: 10.1007/s12672-025-02738-2.
Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive T-cell lymphoma that accounts for only 1% to 2% of all cases of non-Hodgkin lymphoma (NHL). It usually affects middle-aged to elderly men and is associated with fever, night sweats, weight loss, and lymphadenopathy. Approximately 50% of AITL cases have cutaneous manifestations. However, these are not specific. A middle-aged man presented with facial edema with shortness of breath, which was successively misdiagnosed as oral infection, drug dermatitis, and varicella. The fluctuating and nonspecific manifestations of AITL may complicate and delay the definitive diagnosis, thereby affecting treatment and prognosis. This article summarizes the clinical presentation, pathologic features, differential diagnosis, and treatment of this case, emphasizing the importance of lymph node examination in the development of angioedema.
血管免疫母细胞性T细胞淋巴瘤（AITL）是一种罕见的侵袭性T细胞淋巴瘤，仅占所有非霍奇金淋巴瘤（NHL）病例的1%至2%。它通常影响中年至老年男性，并伴有发热、盗汗、体重减轻和淋巴结病。约50%的AITL病例有皮肤表现。然而，这些表现并不具有特异性。一名中年男性出现面部水肿并伴有呼吸急促，先后被误诊为口腔感染、药物性皮炎和水痘。AITL波动且不具特异性的表现可能使明确诊断复杂化并延迟诊断，从而影响治疗和预后。本文总结了该病例的临床表现、病理特征、鉴别诊断和治疗，强调了淋巴结检查在血管性水肿发生中的重要性。
