Waheed Rafia I, Ahmed Gulzar, Tahir Hareem, Khan Dawlat
University of South Dakota Sanford School of Medicine.
S D Med. 2025 May;78(suppl 5):s40.
Colorectal carcinoma (CRC) is the third leading cause of death in the United States despite advancements in screening, early detection, and treatment. This study aims to outline the mortality trends among individuals residing in South Dakota from 1999-2020, categorized by various demographic factors to highlight high-risk populations.
Data from the CDC WONDER database was analyzed, covering the years 1999-2020. CRCrelated deaths were identified using ICD-10 codes C18.0-C18.9. The age-adjusted mortality rates (AAMRs) per 100,000 populations were calculated. Joinpoint regression was used to assess mortality trends and calculate the annual percentage change (APC), with stratification by year, sex, and race/ethnicity.
The study extracted 3,686 CRC-related deaths in South Dakota between 1999 and 2020, with an average AAMR of 16.8 (AAPC: -2.85). The AAMR declined from 22.4 in 1999 to 12.1 in 2020 (APC: -2.85). Men had consistently higher AAMRs than women, decreasing from 26.3 in 1999 to 14.7 in 2020 (APC: -3.03), while women's AAMR declined from 19.2 to 10.5 (APC: -2.77). Only non-Hispanic Whites exhibited a significant decline among racial groups, from 22.9 in 1999 to 10.9 in 2020 (APC: -3.03); data for other races were suppressed or unavailable. AAMRs varied geographically, with the highest in noncore nonmetropolitan counties (18.9), followed by micropolitan (17.7) and small metropolitan (14.5) areas. Mortality risk increased sharply with age, rising from 2.32 in the 35-44 age group to 284.0 in those 85 and older.
CRC mortality in South Dakota declined from 1999-2020, but disparities remain, especially among men, rural areas, and older populations. Enhancing screening, early detection, and healthcare access is crucial for further reduction.
尽管在筛查、早期检测和治疗方面取得了进展，但结直肠癌（CRC）仍是美国第三大死因。本研究旨在概述1999年至2020年居住在南达科他州的个体的死亡率趋势，并按各种人口统计学因素进行分类，以突出高危人群。
分析了疾病控制与预防中心（CDC）WONDER数据库中1999年至2020年的数据。使用国际疾病分类第十版（ICD-10）编码C18.0-C18.9识别与CRC相关的死亡。计算每10万人口的年龄调整死亡率（AAMR）。采用连接点回归评估死亡率趋势并计算年度百分比变化（APC），并按年份、性别和种族/族裔进行分层。
该研究提取了1999年至2020年南达科他州3686例与CRC相关的死亡病例，平均AAMR为16.·8（APC：-2.85）。AAMR从1999年的22.4降至2020年的12.1（APC：-2.85）。男性的AAMR一直高于女性，从1999年的26.3降至2020年的14.7（APC：-3.03），而女性的AAMR从19.2降至10.5（APC：-2.77）。在种族群体中，只有非西班牙裔白人的死亡率显著下降，从1999年的22.9降至2020年的10.9（APC：-3.03）；其他种族的数据被抑制或不可用。AAMR在地理上存在差异，非核心非大都市县最高（18.9），其次是微型都市（17.7）和小型都市（14.5）地区。死亡率风险随年龄急剧增加，从35-44岁年龄组的2.32上升至85岁及以上人群的28·4.0。
1999年至2020年期间，南达科他州的CRC死亡率有所下降，但差异仍然存在，尤其是在男性、农村地区和老年人群体中。加强筛查、早期检测和医疗保健可及性对于进一步降低死亡率至关重要。
