硕大利什曼原虫全身感染的遗传控制：肝内无鞭毛体复制与Lsh基因控制的分离。
Genetic control of systemic Leishmania major infections: dissociation of intrahepatic amastigote replication from control by the Lsh gene.
作者信息
Mock B A, Fortier A H, Potter M, Nacy C A
出版信息
Infect Immun. 1985 Nov;50(2):588-91. doi: 10.1128/iai.50.2.588-591.1985.
Abstract
Systemic disease induced by Leishmania major was estimated by microscopic examination of liver impression smears and determination of numbers of intrahepatic amastigotes in intravenously or subcutaneously infected inbred, hybrid, and congenic mice. The distribution of susceptible phenotypes among these mice, particularly the susceptibility of a strain congenic for Lshr, strongly suggested that Lsh, a gene which controls intrahepatic replication of Leishmania donovani, does not influence systemic disease by L. major.
摘要
通过对肝印片进行显微镜检查以及测定静脉内或皮下感染的近交系、杂交系和同源近交系小鼠肝内无鞭毛体数量，来评估硕大利什曼原虫引起的全身性疾病。这些小鼠中易感表型的分布，特别是对Lshr基因同源近交系的易感性，强烈表明控制杜氏利什曼原虫肝内复制的基因Lsh并不影响硕大利什曼原虫引起的全身性疾病。
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