Höffler D, Wittgens T, Piper C
Infection. 1985;13 Suppl 1:S151-5. doi: 10.1007/BF01644238.
Eleven patients with terminal renal insufficiency requiring dialysis were treated with 3 X 2 g cefotaxime in an open study lasting five days when the clinical findings strongly indicated a serious bacterial infection. The effect of the administration of the high-dose antibiotic on the coagulation system (Quick test, partial thromboplastin time, thrombin time, antithrombin III and platelets) and on brain function (EEG) was investigated. The serum levels showed that the serum concentrations were not abnormally high in cases of terminal renal insufficiency requiring dialysis. In contrast to previous investigations in other beta-lactam antibiotics, no changes in the coagulation system or EEG occurred. On the basis of these findings, no reduction in the dose appears necessary for cefotaxime, if therapy does not exceed five days.
在一项为期五天的开放性研究中，对11例需要透析的终末期肾功能不全患者给予3次，每次2克的头孢噻肟治疗，当时临床检查结果强烈提示存在严重细菌感染。研究了高剂量抗生素给药对凝血系统（奎克试验、部分凝血活酶时间、凝血酶时间、抗凝血酶III和血小板）以及脑功能（脑电图）的影响。血清水平显示，在需要透析的终末期肾功能不全病例中，血清浓度并未异常升高。与之前对其他β-内酰胺类抗生素的研究不同，凝血系统或脑电图未出现变化。基于这些发现，如果治疗不超过五天，头孢噻肟似乎无需减量。
