海藻酸钠对高胆固醇血症患者的降脂作用

[Lipid-lowering effect of sodium alginate in patients with hypercholesterolemia].

作者信息

Zhang Jiawen, Zhang Yan, Zhang Xia, Man Qingqing, Yang Fang, Li Yingying, Zhu Mingyu, Fan Boyi, Tang Guoliang, Xiang Xuesong

机构信息

NHC Key Laboratory of Public Nutrition and Health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Leling City People's Hospital, Dezhou 253600, China.

出版信息

Wei Sheng Yan Jiu. 2025 May;54(3):495-499. doi: 10.19813/j.cnki.weishengyanjiu.2025.03.021.

DOI:10.19813/j.cnki.weishengyanjiu.2025.03.021

PMID:40550618

Abstract

OBJECTIVE

To investigate the effects of sodium alginate(SA) on serum total cholesterol(TC) levels in individuals with hypercholesterolemia.

METHODS

A randomized double-blind controlled trial was conducted on hypercholesterolemic patients(TC≥5.2 mmol/L, n=84), who were divided into a control group and an SA intervention group. General demographic and physical examination data were collected. Serum levels of TC, triglycerides(TG), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) were measured before and after the intervention. Changes in TC, TG, LDL-C, and HDL-C were calculated as baseline values minus post-intervention values(28 days), followed by comparative analyses.

RESULTS

SA showed no significant effects on body weight or body mass index(BMI). However, SA reduced lipid levels: the ΔTC, ΔTG, and ΔLDL-C in the SA intervention group were higher compared to the control group(P<0.05). The lipid-lowering effects increased with higher baseline TC levels(r=0.476, P<0.001). The participants with TC ≥6.2 mmol/L demonstrated significantly higher ΔTC and ΔLDL-C compared to the control group(P<0.01).

CONCLUSION

Sodium alginate significantly reduces serum TC and LDL-C levels in hypercholesterolemic patients, with particularly pronounced effects in patients with TC≥6.2 mmol/L.

摘要

目的

探讨海藻酸钠（SA）对高胆固醇血症患者血清总胆固醇（TC）水平的影响。

方法

对高胆固醇血症患者（TC≥5.2 mmol/L，n = 84）进行随机双盲对照试验，将其分为对照组和SA干预组。收集一般人口统计学和体格检查数据。在干预前后测量血清TC、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平。计算TC、TG、LDL-C和HDL-C的变化，即基线值减去干预后值（28天），然后进行比较分析。

结果

SA对体重或体重指数（BMI）无显著影响。然而，SA降低了血脂水平：SA干预组的ΔTC、ΔTG和ΔLDL-C高于对照组（P<0.05）。降血脂作用随基线TC水平升高而增强（r = 0.476，P<0.001）。与对照组相比，TC≥6.2 mmol/L的参与者的ΔTC和ΔLDL-C显著更高（P<0.01）。