Delaby Constance, Ladang Aurélie, Martinez-Yriarte Jose, Zecca Chiara, Logroscino Giancarlo, Körtvelyessy Peter, Tumani Hayrettin, Parchi Piero, Quadrio Isabelle, Hart Melanie, Olsen Dorte Aalund, Alcolea Daniel, Blennow Kaj, Fortea Juan, Lleo Alberto, Algeciras-Schimnich Alicia, Ayrignac Xavier, Bedel Aurélie, Santos Gustavo A A, Borelli Wyllians, Bouaziz-Amar Elodie, Baldeiras Inês, Bigot-Corbel Edith, Bjerke Maria, Carretero Perez Mercedes, Casoli Tiziana, Chabrashvili Tinatin, Chapman Miles D, Cusato Jessica, Dursun Erdinc, Fourier Anthony, Galimberti Daniela, Gezen-Ak Duygu, Gordon Brian A, Gouju Julien, de Las Heras Florez Silvia, Hernandez Sanchez Juanjo, Herwerth Marina, Imperiale Daniele, Kaczorowski Flora, Kasuga Kensaku, Keshavan Ashvini, Khalil Michael, Kuhle Jens, Leithner Christoph, Lewczuk Piotr, Letournel Franck, Tsolaki Magda, Giuffrè Guido Maria, Blanc Marie-Céline, Mroczko Barbara, Martínez Rodríguez Jose Enrique, Musso Giulia, Kulczynska-Przybik Agnieszka, Nogueira Léonor, Paquet Claire, Baiardi Simone, Gaetani Lorenzo, Parnetti Lucilla, Perez Garay Raquel, Poesen Koen, Quillard-Muraine Muriel, Rodriguez Borja Enrique, Schraen Susanna, Terracciano Daniela, Bachhuber Franziska, Halbgebauer Steffen, Tzartos Socrates, Tzartos John, Unterwalder Nadine, Vermunt Lisa, Wellington Cheryl L, Zetterberg Henrik, Teunissen Charlotte, Lehmann Sylvain
Univ Montpellier, LBPC-PPC, CHU Montpellier, INSERM, Montpellier, France.
Department of Unitat de Memoria, Hospital de la Santa Creu iSant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.
Alzheimers Dement. 2025 Jun;21(6):e70343. doi: 10.1002/alz.70343.
Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts.
We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.
Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%).
Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.
Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.
神经丝轻链（NfL）定量有助于诊断和预测神经系统疾病，但各中心的临床和实验室操作存在差异。结果解释和报告的差异进一步挑战了检测的互换性。本研究旨在回顾在不同背景下常规临床实践中用于NfL测量的全球分析和分析后方法。
我们成立了一个国际工作组（WG），并向其成员分发了一份调查问卷，以收集关于使用背景（COU）、（预）分析方法、临界值使用情况以及NfL测量结果的解释和报告等信息。
在这些中心中，63%检测脑脊液（CSF）中的NfL，87%检测血液中的NfL，53%两者都检测。COU很普遍，50%根据出版物定义病理临界值，42%考虑年龄因素。报告主要通过数值结果进行（95%）。
在各种临床背景下统一临界值、报告和解释将有助于将这种生物标志物纳入常规临床实践。
对常规临床实践中神经丝轻链（NfL）测量的当前分析和分析后方法进行独特的国际概述。针对每种神经学应用的定制表格。统一NfL测量临界值、报告和解释的策略。
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