Strasberg B, Arditti A, Sclarovsky S, Lewin R F, Buimovici B, Agmon J
Int J Cardiol. 1985 Jan;7(1):47-58. doi: 10.1016/0167-5273(85)90172-x.
We tested the efficacy of intravenous amiodarone (5 mg/kg) in slowing ventricular response and/or restoring sinus rhythm in 26 patients with paroxysmal or new atrial fibrillation with fast ventricular response. There were 16 men and 10 women with ages ranging from 35 to 84 years, mean 63 years. Intravenous amiodarone initially slowed the ventricular response in all patients from 143 +/- 27 to 96 +/- 10 beats/min (P less than 0.001). Twelve patients (46%) reverted to sinus rhythm within the first 30 min (range 5 to 30 min, mean 14 +/- 9 min). One patient reverted to atrial flutter after 10 min and 40 min later to sinus rhythm. Six patients (23%) converted to sinus rhythm after 2 to 8 hr and in these 6 cases, the initial slowing in ventricular response obtained with amiodarone persisted until conversion. Seven patients (27%) did not convert to sinus rhythm following amiodarone administration and they required further medical therapy to slow the ventricular response and/or to convert to sinus rhythm. No serious side effects from drug administration were noted. Intravenous amiodarone appears as a highly effective medication in the conversion or control of new onset atrial fibrillation with fast ventricular response.
我们对26例伴有快速心室反应的阵发性或新发房颤患者，测试了静脉注射胺碘酮（5mg/kg）减慢心室反应和/或恢复窦性心律的疗效。其中男性16例，女性10例，年龄35至84岁，平均63岁。静脉注射胺碘酮最初使所有患者的心室反应从143±27次/分钟减慢至96±10次/分钟（P＜0.001）。12例患者（46%）在最初30分钟内恢复窦性心律（范围5至30分钟，平均14±9分钟）。1例患者在10分钟时转为心房扑动，40分钟后恢复窦性心律。6例患者（23%）在2至8小时后转为窦性心律，在这6例中，胺碘酮引起的心室反应最初减慢一直持续到转为窦性心律。7例患者（27%）在给予胺碘酮后未转为窦性心律，他们需要进一步的药物治疗来减慢心室反应和/或转为窦性心律。未观察到给药引起的严重副作用。静脉注射胺碘酮似乎是一种治疗伴有快速心室反应的新发房颤转复或控制的高效药物。
