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2
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本文引用的文献

1
B vitamins and the 2024 Lancet Commission on dementia.B族维生素与《柳叶刀》2024年痴呆症委员会
Lancet. 2025 Feb 22;405(10479):623. doi: 10.1016/S0140-6736(25)00252-1.
2
Associations among dietary 1-carbon metabolism nutrients, genetic risk, and Alzheimer disease: a prospective cohort study.饮食 1 碳代谢营养素、遗传风险与阿尔茨海默病之间的关联：一项前瞻性队列研究。
Am J Clin Nutr. 2024 Nov;120(5):1009-1018. doi: 10.1016/j.ajcnut.2024.08.027. Epub 2024 Aug 30.
3
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.《痴呆症的预防、干预与照护：柳叶刀常设委员会2024年报告》
Lancet. 2024 Aug 10;404(10452):572-628. doi: 10.1016/S0140-6736(24)01296-0. Epub 2024 Jul 31.
4
Concurrent nutrient deficiencies are associated with dementia incidence.同时存在营养缺乏与痴呆症发病有关。
Alzheimers Dement. 2024 Jul;20(7):4594-4601. doi: 10.1002/alz.13884. Epub 2024 Jun 12.
5
Association of Long-term Exposure to Air Pollution and Dementia Risk: The Role of Homocysteine, Methionine, and Cardiovascular Burden.长期暴露于空气污染与痴呆风险的关联：同型半胱氨酸、蛋氨酸和心血管负担的作用。
Neurology. 2023 Sep 19;101(12):e1231-e1240. doi: 10.1212/WNL.0000000000207656. Epub 2023 Jul 13.
6
Association of Vitamin B Status with Risk of Dementia in Cohort Studies: A Systematic Review and Meta-Analysis.维生素 B 状态与队列研究中痴呆风险的关联：系统评价和荟萃分析。
J Am Med Dir Assoc. 2022 Nov;23(11):1826.e21-1826.e35. doi: 10.1016/j.jamda.2022.05.022. Epub 2022 Jun 29.
7
DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial.二十二碳六烯酸（DHA）状况影响 B 族维生素补充对认知衰老的影响：B 证明试验的事后分析。
Eur J Nutr. 2022 Oct;61(7):3731-3739. doi: 10.1007/s00394-022-02924-w. Epub 2022 Jun 15.
8
The effects of multi-nutrient formulas containing a combination of -3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta-analysis.含长链多不饱和脂肪酸和维生素 B 组合的多种营养素配方对老年人认知功能的影响：系统评价和荟萃分析。
Br J Nutr. 2023 Feb 14;129(3):428-441. doi: 10.1017/S0007114522001283. Epub 2022 Apr 27.
9
Effectiveness of B Vitamins and Their Interactions with Aspirin in Improving Cognitive Functioning in Older People with Mild Cognitive Impairment: Pooled Post-Hoc Analyses of Two Randomized Trials.B族维生素及其与阿司匹林相互作用对改善轻度认知障碍老年人认知功能的有效性：两项随机试验的汇总事后分析
J Nutr Health Aging. 2021;25(10):1154-1160. doi: 10.1007/s12603-021-1708-1.
10
The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials.二氢叶酸还原酶 19 位碱基缺失改变了 B 族维生素治疗轻度认知障碍的有益作用：两项随机安慰剂对照试验的汇总研究。
Hum Mol Genet. 2022 Mar 31;31(7):1151-1158. doi: 10.1093/hmg/ddab246.

关于同型半胱氨酸、B族维生素与痴呆症的争论。

Concerning the debate about homocysteine, B vitamins, and dementia.

作者信息

Miller Joshua W, McCaddon Andrew, Yu Jin-Tai, Hooshmand Babak, Refsum Helga, Smith A David

机构信息

Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA.

Faculty of Social and Life Sciences, Wrexham University, Wrexham, UK.

出版信息

J Alzheimers Dis. 2025 Jun 23;106(3):13872877251350297. doi: 10.1177/13872877251350297.

DOI:10.1177/13872877251350297
PMID:40551597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12284325/
Abstract

It is important to identify modifiable risk factors for dementia and to introduce policies to implement their modification. The Lancet Commission on Dementia Prevention, Intervention and Care failed to identify raised plasma homocysteine as a risk factor, despite considerable evidence; hence there is a need for a debate on this matter.

摘要

识别痴呆症的可改变风险因素并推行相关政策以实现对这些因素的改变非常重要。《柳叶刀》痴呆症预防、干预与护理委员会尽管有大量证据，却未能将血浆同型半胱氨酸升高识别为一个风险因素；因此有必要就此问题展开辩论。