Prednisolone elimination in human saliva.

The elimination of prednisolone in saliva was studied following administration of intravenous doses of 16, 32, 48 and 64 mg to 7 healthy human subjects. While there was an approximate relationship between salivary and plasma concentrations of prednisolone a wide inter- and intraindividual variation in the ratio of the concentration in these two body fluids was observed. Salivary estimations of prednisolone concentration cannot replace plasma concentrations in biopharmaceutical studies.